RHG9 Antibody - #DF4428
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4428, RRID:AB_2836783.
折りたたみ／展開
10C; ARHGAP9; FLJ16525; MGC1295; RGL1; RHG09_HUMAN; Rho GTPase activating protein 9; Rho GTPase-activating protein 9; Rho type GTPase activating protein 9; Rho-type GTPase-activating protein 9;
免疫原
- Q9BRR9 RHG09_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSSRWWPSSWGILGLGPRSPPRGSQLCALYAFTYTGADGQQVSLAEGDRFLLLRKTNSDWWLARRLEAPSTSRPIFVPAAYMIEESIPSQSPTTVIPGQLLWTPGPKLFHGSLEELSQALPSRAQASSEQPPPLPRKMCRSVSTDNLSPSLLKPFQEGPSGRSLSQEDLPSEASASTAGPQPLMSEPPVYCNLVDLRRCPRSPPPGPACPLLQRLDAWEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEGTQTLKRNNDVLQPQAKGFRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREAPTGRDQGSGDRENPLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BRR9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S20 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S128 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| S161 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| T178 | Phosphorylation | Uniprot | |
| S186 | Phosphorylation | Uniprot | |
| Y191 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| T283 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| K333 | Ubiquitination | Uniprot | |
| R386 | Methylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S467 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S475 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S496 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| K568 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot |
研究背景
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.
Interacts with FASLG.
A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.
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