ARHGEF11 Antibody - #DF4431
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4431, RRID:AB_2836786.
折りたたみ／展開
ARHGB_HUMAN; ARHGEF 11; ARHGEF11; DKFZp667F1223; Glutamate transporter EAAT4 associated protein 48; GTRAP 48; GTRAP48; KIAA0380; OTTHUMP00000038716; OTTHUMP00000038717; PDZ RHOGEF; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator;
免疫原
- O15085 ARHGB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O15085 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| S29 | Phosphorylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S38 | Phosphorylation | Uniprot | |
| T40 | Phosphorylation | Uniprot | |
| T41 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| S251 | Phosphorylation | Uniprot | |
| T254 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| S359 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| T421 | Phosphorylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| T590 | Phosphorylation | Uniprot | |
| S592 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot | |
| S633 | Phosphorylation | Uniprot | |
| S635 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| S653 | Phosphorylation | Uniprot | |
| S654 | Phosphorylation | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| T656 | Phosphorylation | Uniprot | |
| S657 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| S663 | Phosphorylation | Uniprot | |
| T668 | Phosphorylation | Uniprot | |
| T672 | Phosphorylation | Uniprot | |
| S679 | Phosphorylation | Uniprot | |
| S851 | Phosphorylation | Uniprot | |
| K925 | Acetylation | Uniprot | |
| K938 | Ubiquitination | Uniprot | |
| T1063 | Phosphorylation | Uniprot | |
| S1064 | Phosphorylation | Uniprot | |
| S1065 | Phosphorylation | Uniprot | |
| S1135 | Phosphorylation | Uniprot | |
| S1155 | Phosphorylation | Uniprot | |
| S1168 | Phosphorylation | Uniprot | |
| T1292 | Phosphorylation | Uniprot | |
| S1295 | Phosphorylation | Uniprot | |
| S1300 | Phosphorylation | Uniprot | |
| S1411 | Phosphorylation | Uniprot | |
| S1413 | Phosphorylation | Uniprot | |
| S1452 | Phosphorylation | Uniprot | |
| S1457 | Phosphorylation | Uniprot | |
| S1458 | Phosphorylation | Uniprot | |
| T1461 | Phosphorylation | Uniprot | |
| T1462 | Phosphorylation | Uniprot | |
| S1466 | Phosphorylation | Uniprot | |
| T1475 | Phosphorylation | Uniprot | |
| S1478 | Phosphorylation | Uniprot | |
| S1480 | Phosphorylation | Uniprot | |
| S1489 | Phosphorylation | Uniprot | |
| S1491 | Phosphorylation | Uniprot | |
| C1500 | S-Nitrosylation | Uniprot | |
| S1519 | Phosphorylation | Uniprot |
研究背景
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.
Cytoplasm. Membrane.
Note: Translocated to the membrane upon stimulation.
Ubiquitously expressed.
Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus).
The poly-Pro region is essential for plasma membrane localization upon stimulation.
研究領域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
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