DVL3 Antibody - #DF4455
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4455, RRID:AB_2836810.
折りたたみ／展開
Dishevelled 3 (homologous to Drosophila dsh); Dishevelled 3; Dishevelled 3, dsh homolog (Drosophila); Dishevelled, dsh homolog 3 (Drosophila); Dishevelled-3; DSH homolog 3; dvl3; DVL3_HUMAN; KIAA0208; OTTHUMP00000210777; OTTHUMP00000210778; Segment polarity protein dishevelled homolog DVL 3; Segment polarity protein dishevelled homolog DVL-3;
免疫原
- Q92997 DVL3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92997 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Ubiquitination | Uniprot | ||
| T15 | Phosphorylation | Uniprot | |
| R27 | Methylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S125 | Phosphorylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| S140 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| R212 | Methylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| S237 | Phosphorylation | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| Y257 | Phosphorylation | Uniprot | |
| S268 | Phosphorylation | Uniprot | |
| R271 | Methylation | Uniprot | |
| S280 | Phosphorylation | Uniprot | |
| K283 | Ubiquitination | Uniprot | |
| S311 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| R342 | Methylation | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| S421 | Phosphorylation | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | Uniprot | |
| S566 | Phosphorylation | Uniprot | |
| S567 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| S573 | Phosphorylation | Uniprot | |
| S575 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| S596 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S601 | Phosphorylation | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| S605 | Phosphorylation | Uniprot | |
| T608 | Phosphorylation | Uniprot | |
| T609 | Phosphorylation | Uniprot | |
| S611 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| S633 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| S639 | Phosphorylation | Uniprot | |
| S642 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| S689 | Phosphorylation | Uniprot | |
| S697 | Phosphorylation | Uniprot | |
| R698 | Methylation | Uniprot | |
| S700 | Phosphorylation | Uniprot |
研究背景
Involved in the signal transduction pathway mediated by multiple Wnt genes.
Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Arginine methylation may function as a switch in regulation of function in Wnt signaling.
Cytoplasm.
Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2. Interacts with DAAM2 (By similarity).
Belongs to the DSH family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells. (View pathway)
· Environmental Information Processing > Signal transduction > mTOR signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Basal cell carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Breast cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma. (View pathway)
· Human Diseases > Cancers: Specific types > Gastric cancer. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
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