PPP2R3B Antibody - #DF4485
| 製品: | PPP2R3B Antibody |
| カタログ: | DF4485 |
| タンパク質の説明: | Rabbit polyclonal antibody to PPP2R3B |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Pig, Zebrafish, Chicken, Xenopus |
| 分子量: | 70 KD; 65kD(Calculated). |
| ユニプロット: | Q9Y5P8 |
| RRID: | AB_2836836 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4485, RRID:AB_2836836.
折りたたみ／展開
NY REN 8; NY REN 8 antigen; P2R3B_HUMAN; PP2A B'' subunit PR48; PP2A subunit B isoform PR48; PP2A subunit B PR48 isoform; PPP2R3B; PPP2R3L; PPP2R3LY; PR 48; PR48; Protein phosphatase 2 (formerly 2A) regulatory subunit B'' beta; Protein phosphatase 2 regulatory subunit B'' beta; Protein phosphatase 2A 48 kDa regulatory subunit; Serine/threonine protein phosphatase 2A 48kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta;
免疫原
- Q9Y5P8 P2R3B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPPGKVLQPVLKMKVDELFLYWLSEASTQRMLQDCLRRIKAPGRDQPTPGDGEQPGAWPTAPLAAPRPSGLEPPGTPGPGPALPLGAASSPRNAPHVRGTRRSAGTRVVQTRKEEPLPPATSQSIPTFYFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKEQISLLRDGDSGGPELSDWEKYAAEEYDILVAEETAGEPWEDGFEAELSPVEQKLSALRSPLAQRPFFEAPSPLGAVDLYEYACGDEDLEPL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y5P8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S90 | Phosphorylation | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| K350 | Ubiquitination | Uniprot | |
| S357 | Phosphorylation | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K483 | Ubiquitination | Uniprot |
研究背景
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Nucleus.
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6. Interacts with NOD2.
研究領域
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Genetic Information Processing > Translation > mRNA surveillance pathway.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Dopaminergic synapse.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.