SHANK2 Antibody - #DF4501
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4501, RRID:AB_2836852.
折りたたみ／展開
AUTS17; Cortactin binding protein 1; Cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CortBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; KIAA1022; Proline rich synapse associated protein 1; Proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHAN2_RAT; SHANK; Shank2; SPANK-3;
免疫原
- Q9UPX8 SHAN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPASKPSRAAENMAVEPRVATIKQRPSSRCFPAGSDMNSVYERQGIAVMTPTVPGSPKAPFLGIPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPKSPTPRVYGTIKPAFNQNSAAKVSPATRSDTVATMMREKGMYFRRELDRYSLDSEDLYSRNAGPQANFRNKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQAPEPPSQLRPDESLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRTRPSMFPEEGDFADEDSAEQLSSPMPSATPREPENHFVGGAEASAPGEAGRPLNSTSKAQGPESSPAVPSASSGTAGPGNYVHPLTGRLLDPSSPLALALSARDRAMKESQQGPKGEAPKADLNKPLYIDTKMRPSLDAGFPTVTRQNTRGPLRRQETENKYETDLGRDRKGDDKKNMLIDIMDTSQQKSAGLLMVHTVDATKLDNALQEEDEKAEVEMKPDSSPSEVPEGVSETEGALQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASVDLDEDFIFTEPLPPPLEFANSFDIPDDRAASVPALSDLVKQKKSDTPQSPSLNSSQPTNSADSKKPASLSNCLPASFLPPPESFDAVADSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGENVDTCTVYADGQAFMVDKPPVPPKPKMKPIIHKSNALYQDALVEEDVDSFVIPPPAPPPPPGSAQPGMAKVLQPRTSKLWGDVTEIKSPILSGPKANVISELNSILQQMNREKLAKPGEGLDSPMGAKSASLAPRSPEIMSTISGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGTRRAPSPVVSPTEMNKETLPAPLSAATASPSPALSDVFSLPSQPPSGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UPX8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S41 | Phosphorylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| S65 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S76 | Phosphorylation | Uniprot | |
| T84 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| Y88 | Phosphorylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| Y144 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| S234 | Phosphorylation | Uniprot | |
| T339 | Phosphorylation | Uniprot | |
| T341 | Phosphorylation | Uniprot | |
| T349 | Phosphorylation | Uniprot | |
| T363 | Phosphorylation | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| S372 | Phosphorylation | Uniprot | |
| Y437 | Phosphorylation | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| S470 | Phosphorylation | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| S518 | Phosphorylation | Uniprot | |
| Y538 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S559 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| T564 | Phosphorylation | Uniprot | |
| Y580 | Phosphorylation | Uniprot | |
| S581 | Phosphorylation | Uniprot | |
| S584 | Phosphorylation | Uniprot | |
| Y588 | Phosphorylation | Uniprot | |
| Y610 | Phosphorylation | Uniprot | |
| S611 | Phosphorylation | Uniprot | |
| Y622 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| S649 | Phosphorylation | Uniprot | |
| T662 | Phosphorylation | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| S665 | Phosphorylation | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S725 | Phosphorylation | Uniprot | |
| T726 | Phosphorylation | Uniprot | |
| S813 | Phosphorylation | Uniprot | |
| Y822 | Phosphorylation | Uniprot | |
| T827 | Phosphorylation | Uniprot | |
| S835 | Phosphorylation | Uniprot | |
| Y869 | Phosphorylation | Uniprot | |
| S877 | Phosphorylation | Uniprot | |
| T890 | Phosphorylation | Uniprot | |
| T899 | Phosphorylation | Uniprot | |
| Y903 | Phosphorylation | Uniprot | |
| S931 | Phosphorylation | Uniprot | |
| T939 | Phosphorylation | Uniprot | |
| T943 | Phosphorylation | Uniprot | |
| S1001 | Phosphorylation | Uniprot | |
| S1051 | Phosphorylation | Uniprot | |
| S1064 | Phosphorylation | Uniprot | |
| S1069 | Phosphorylation | Uniprot | |
| S1071 | Phosphorylation | Uniprot | |
| S1080 | Phosphorylation | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| S1234 | Phosphorylation | Uniprot | |
| S1269 | Phosphorylation | Uniprot | |
| S1282 | Phosphorylation | Uniprot | |
| S1330 | Phosphorylation | Uniprot | |
| S1334 | Phosphorylation | Uniprot | |
| S1382 | Phosphorylation | Uniprot | |
| S1384 | Phosphorylation | Uniprot | |
| S1386 | Phosphorylation | Uniprot | |
| S1395 | Phosphorylation | Uniprot |
研究背景
Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Apical cell membrane. Cytoplasm. Cell junction>Synapse. Cell junction>Synapse>Postsynaptic density. Cell projection>Growth cone. Cell projection>Dendritic spine.
Note: Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).
Isoform 3 is present in epithelial colonic cells (at protein level).
Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with CTTN/cortactin SH3 domain, DLGAP1/GKAP and alpha-latrotoxin receptor 1. Interacts with DNM2, DBNL, GRID2, BAIAP2, SLC9A3, PLCB3 and CFTR. Interacts (via proline-rich region) with PDE4D. Interacts with ABI1 (via SH3 domain).
The PDZ domain is required for interaction with GRID2, PLCB3, CFTR and SLC9A3.
Belongs to the SHANK family.
研究領域
· Organismal Systems > Nervous system > Glutamatergic synapse.
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