製品: SIRPB1 Antibody
カタログ: DF4507
タンパク質の説明: Rabbit polyclonal antibody to SIRPB1
アプリケーション: WB IF/ICC
反応性: Human, Rat
分子量: 48 KD; 43kD(Calculated).
ユニプロット: O00241
RRID: AB_2836858

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Rat
クローナリティ:
Polyclonal
特異性:
SIRPB1 Antibody detects endogenous levels of total SIRPB1.
RRID:
AB_2836858
引用形式: Affinity Biosciences Cat# DF4507, RRID:AB_2836858.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

CD172 antigen like family member B; CD172b; CD172b antigen; DKFZp686A05192; Signal regulatory protein beta 1; SIRP BETA 1; SIRP beta 1 isoform 3;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
O00241 SIRB1_HUMAN:

Detected in monocytes and dendritic cells.

タンパク質配列:
MPVPASWPHLPSPFLLMTLLLGRLTGVAGEDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLLVALLLGPKLLLVVGVSAIYICWKQKA

PTMs - O00241 基板として

Site PTM Type Enzyme
K82 Ubiquitination
K97 Ubiquitination
Y119 Phosphorylation
K182 Ubiquitination
N244 N-Glycosylation

研究背景

機能:

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP.

PTMs:

N-glycosylated.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Detected in monocytes and dendritic cells.

サブユニット構造:

Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK.

研究領域

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

参考文献

1). Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation. Neural Plasticity, 2021 (PubMed: 34471408) [IF=3.1]

Application: WB    Species: Mouse    Sample: hippocampus tissue

Figure 1 The PERK pathway but not the ATF-6 or IRE-1 pathway was activated. (a) The expression levels of p-PERK, p-elf2α, and ATF-4 were increased in the hippocampus after 2 weeks of IH exposure (n = 4). The expression of p-IRE1 (b) and p-ATF-6 (c) was not altered (n = 4). ∗P < 0.05; ∗∗P < 0.01; ns: not significant.

Application: WB    Species: mouse    Sample: hippocampal

Figure 1: |The PERK pathway but not the ATF-6 or IRE-1 pathway was activated. (a) The expression levels of p-PERK, p-elf2α, and ATF-4 were increased in the hippocampus after 2 weeks of IH exposure (n = 4). The expression of p-IRE1 (b) and p-ATF-6 (c) was not altered(n = 4). ∗P < 0:05; ∗∗P < 0:01; ns: not significant.

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