SNX4 Antibody - #DF4538
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4538, RRID:AB_2836889.
折りたたみ／展開
ATG24B; SNX 4; snx4; SNX4_HUMAN; Sorting nexin 4; Sorting nexin-4;
免疫原
- O95219 SNX4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95219 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| S97 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| C172 | S-Nitrosylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K205 | Methylation | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| T210 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| R247 | Methylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K339 | Ubiquitination | Uniprot | |
| T347 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| K356 | Methylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K419 | Acetylation | Uniprot | |
| K444 | Ubiquitination | Uniprot | |
| K449 | Ubiquitination | Uniprot |
研究背景
Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation.
Early endosome. Early endosome membrane>Peripheral membrane protein>Cytoplasmic side.
Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC).
Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2. Interacts with BIN1.
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.
Belongs to the sorting nexin family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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