SFRS7 Antibody - #DF4544
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4544, RRID:AB_2836895.
折りたたみ／展開
9G8; AAG3; arginine/serine-rich 7; HSSG1; RBM37; Serine/arginine-rich splicing factor 7; Splicing factor 9G8; Splicing factor; Splicing factor, arginine/serine rich 7; SRSF7; SRSF7_HUMAN; ZCCHC20; ZCRB2;
免疫原
- Q16629 SRSF7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16629 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y4 | Phosphorylation | Uniprot | |
| Y7 | Phosphorylation | Uniprot | |
| K12 | Sumoylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| Y14 | Phosphorylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| K24 | Acetylation | Uniprot | |
| K24 | Sumoylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| Y33 | Phosphorylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| K70 | Acetylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| C73 | S-Nitrosylation | Uniprot | |
| R98 | Methylation | Uniprot | |
| R105 | Methylation | Uniprot | |
| Y107 | Phosphorylation | Uniprot | |
| K112 | Acetylation | Uniprot | |
| K112 | Ubiquitination | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S155 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S163 | Phosphorylation | Uniprot | |
| S165 | Phosphorylation | Uniprot | |
| S167 | Phosphorylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| K185 | Acetylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| Y189 | Phosphorylation | Uniprot | |
| S192 | Phosphorylation | Uniprot | |
| S194 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S198 | Phosphorylation | Uniprot | |
| S200 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| S213 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S227 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| R236 | Methylation | Uniprot |
研究背景
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Extensively phosphorylated on serine residues in the RS domain.
Nucleus. Cytoplasm.
Brain, liver, kidney and lung.
Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1.
Belongs to the splicing factor SR family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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