VPS26B Antibody - #DF4606
| 製品: | VPS26B Antibody |
| カタログ: | DF4606 |
| タンパク質の説明: | Rabbit polyclonal antibody to VPS26B |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 45 KD; 39kD(Calculated). |
| ユニプロット: | Q4G0F5 |
| RRID: | AB_2836970 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4606, RRID:AB_2836970.
折りたたみ／展開
Pep8b; Vacuolar protein sorting 26 homolog B (S. pombe); Vacuolar protein sorting 26 homolog B (yeast); Vesicle protein sorting 26B;
免疫原
A synthesized peptide derived from human VPS26B, corresponding to a region within the internal amino acids.
- Q4G0F5 VP26B_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSFFGFGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLALKNPNKRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYESYTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAPVRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDIVRKSMSHQAAIASQRFEGTTSLGEVRTPSQLSDNNCRQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).
Cytoplasm. Membrane>Peripheral membrane protein. Early endosome. Late endosome.
Note: Localizes to early and late endosomal structures (By similarity).
Belongs to the VPS26 family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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