WASF3 Antibody - #DF4619
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4619, RRID:AB_2836983.
折りたたみ／展開
KIAA0900; Protein WAVE-3; Protein WAVE3; SCAR3; Verprolin homology domain containing protein 3; Verprolin homology domain-containing protein 3; WASF3; WASF3_HUMAN; WASP family protein member 3; WAVE3; Wiskott Aldrich syndrome protein family member 3; Wiskott-Aldrich syndrome protein family member 3;
免疫原
- Q9UPY6 WASF3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPASQAAEHEYRPPSASARHMALNRPQQPPPPPPPQAPEGSQASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPGSSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UPY6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y151 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y156 | Phosphorylation | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| S223 | Phosphorylation | Uniprot | |
| Y225 | Phosphorylation | Uniprot | |
| S235 | Phosphorylation | Uniprot | |
| T246 | Phosphorylation | Uniprot | |
| Y248 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y286 | Phosphorylation | Uniprot | |
| Y337 | Phosphorylation | P00519 (ABL1) | Uniprot |
| Y486 | Phosphorylation | P00519 (ABL1) | Uniprot |
研究背景
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
Cytoplasm>Cytoskeleton.
Expressed in ovary and brain.
Binds actin and the Arp2/3 complex.
Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Belongs to the SCAR/WAVE family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Human Diseases > Cancers: Overview > Choline metabolism in cancer. (View pathway)
· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis. (View pathway)
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