SLC38A2 Antibody - #DF4673
| 製品: | SLC38A2 Antibody |
| カタログ: | DF4673 |
| タンパク質の説明: | Rabbit polyclonal antibody to SLC38A2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Horse, Rabbit, Dog |
| 分子量: | 50 KD; 56kD(Calculated). |
| ユニプロット: | Q96QD8 |
| RRID: | AB_2837024 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4673, RRID:AB_2837024.
折りたたみ／展開
Amino acid transporter 2; Amino acid transporter A2; ATA2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2;
免疫原
Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
- Q96QD8 S38A2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIGAMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIFPIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96QD8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K2 | Ubiquitination | Uniprot | |
| K3 | Ubiquitination | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S12 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| Y28 | Phosphorylation | Uniprot | |
| Y30 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K38 | Methylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| S39 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| Y134 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| Y217 | Phosphorylation | Uniprot | |
| Y220 | Phosphorylation | Uniprot | |
| T221 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot |
研究背景
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta.
Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.
Cell membrane>Multi-pass membrane protein.
Note: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.
Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).
Belongs to the amino acid/polyamine transporter 2 family.
研究領域
· Organismal Systems > Nervous system > Glutamatergic synapse.
· Organismal Systems > Nervous system > GABAergic synapse.
· Organismal Systems > Digestive system > Protein digestion and absorption.
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