TEAD3 Antibody - #DF4677
| 製品: | TEAD3 Antibody |
| カタログ: | DF4677 |
| タンパク質の説明: | Rabbit polyclonal antibody to TEAD3 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 49 KD; 49kD(Calculated). |
| ユニプロット: | Q99594 |
| RRID: | AB_2837028 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4677, RRID:AB_2837028.
折りたたみ／展開
DTEF 1; DTEF-1; DTEF1; ETFR 1; ETFR1; TEA domain family member 3; TEA domain family member 5; TEAD 3; TEAD-3; Tead3; TEAD3_HUMAN; TEAD5; TEF 5; TEF5; Transcriptional enhancer factor 5; Transcriptional enhancer factor TEF 5 (DTEF 1); Transcriptional enhancer factor TEF 5; Transcriptional enhancer factor TEF-5;
免疫原
- Q99594 TEAD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q99594 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S11 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S61 | Phosphorylation | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| Y76 | Phosphorylation | Uniprot | |
| K83 | Methylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| S145 | Phosphorylation | Uniprot | |
| S148 | Phosphorylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| K279 | Acetylation | Uniprot | |
| K283 | Acetylation | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| Y350 | Phosphorylation | Uniprot |
研究背景
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Nucleus.
Preferentially expressed in the placenta.
Interacts with YAP1 and WWTR1/TAZ.
研究領域
· Environmental Information Processing > Signal transduction > Hippo signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Hippo signaling pathway - multiple species. (View pathway)
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