IL18R1 Antibody - #DF4712
| 製品: | IL18R1 Antibody |
| カタログ: | DF4712 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL18R1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human |
| 予測: | Rabbit |
| 分子量: | 65 KD; 62kD(Calculated). |
| ユニプロット: | Q13478 |
| RRID: | AB_2837063 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4712, RRID:AB_2837063.
折りたたみ／展開
CD218 antigen-like family member A; CD218a; CDw218a; CDw218a antigen; IL 1Rrp; IL-18R-1; IL-18R1; IL-1Rrp; IL1 receptor related protein; IL1 receptor-related protein; IL18R_HUMAN; IL18R1; IL18RA; Il18ralpha; IL1R-rp; IL1RRP; Interleukin 18 receptor 1; Interleukin 18 receptor, alpha chain; Interleukin-18 receptor 1;
免疫原
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
- Q13478 IL18R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13478 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N91 | N-Glycosylation | Uniprot | |
| N102 | N-Glycosylation | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| N150 | N-Glycosylation | Uniprot | |
| N197 | N-Glycosylation | Uniprot | |
| N203 | N-Glycosylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| N236 | N-Glycosylation | Uniprot | |
| N297 | N-Glycosylation | Uniprot | |
| T483 | Phosphorylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| K501 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot |
研究背景
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells. Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
N-glycosylated. N-linked glycosyl chains contribute to ligand recognition and intra-receptor interactions required for formation of an active ternary receptor complex.
Membrane>Single-pass type I membrane protein.
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells.
Forms a ternary complex with IL18 and IL18RAP. Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).
The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Belongs to the interleukin-1 receptor family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.