TRAF4 Antibody - #DF4728
| 製品: | TRAF4 Antibody |
| カタログ: | DF4728 |
| タンパク質の説明: | Rabbit polyclonal antibody to TRAF4 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 53 KD; 54kD(Calculated). |
| ユニプロット: | Q9BUZ4 |
| RRID: | AB_2837079 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4728, RRID:AB_2837079.
折りたたみ／展開
CART 1; CART1; cysteine rich domain associated with ring and TRAF domain; Cysteine rich domain associated with RING and Traf domains protein 1; Cysteine-rich domain associated with RING and Traf domains protein 1; Malignant 62; Metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF 83; RNF83; TNF receptor associated factor 4; TNF receptor-associated factor 4; TRAF 4; Traf4; TRAF4_HUMAN; tumor necrosis receptor-associated factor 4A;
免疫原
Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
- Q9BUZ4 TRAF4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BUZ4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y6 | Phosphorylation | Uniprot | |
| K7 | Ubiquitination | Uniprot | |
| K11 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| Y166 | Phosphorylation | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K200 | Ubiquitination | Uniprot | |
| S209 | Phosphorylation | Uniprot | |
| Y212 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| S426 | Phosphorylation | O15111 (CHUK) | Uniprot |
| S430 | Phosphorylation | Uniprot | |
| K438 | Ubiquitination | Uniprot |
研究背景
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
Polyubiquitinated, leading to its proteasomal degradation.
Cytoplasm. Nucleus. Cytoplasm>Perinuclear region. Cell junction>Tight junction. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton.
Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6.
The coiled coil domain mediates homo- and hetero-oligomerization.
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Belongs to the TNF receptor-associated factor family. B subfamily.
研究領域
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Small cell lung cancer. (View pathway)
· Organismal Systems > Immune system > IL-17 signaling pathway. (View pathway)
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