RFC2 Antibody - #DF4735
| 製品: | RFC2 Antibody |
| カタログ: | DF4735 |
| タンパク質の説明: | Rabbit polyclonal antibody to RFC2 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 39 KD; 39kD(Calculated). |
| ユニプロット: | P35250 |
| RRID: | AB_2837086 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4735, RRID:AB_2837086.
折りたたみ／展開
A1 40 kDa subunit; A1; Activator 1 40 kDa subunit; Activator 1; Activator 1 subunit 2; MGC3665; OTTHUMP00000160645; OTTHUMP00000160646; Replication factor C (activator 1) 2 40kDa; Replication factor C (activator 1) 2; Replication factor C 2; Replication factor C 40 kDa subunit; Replication factor C subunit 2; RF C 40 kDa subunit; RF-C 40 kDa subunit; RFC 2; RFC 40; RFC 40 kDa subunit; RFC2; RFC2_HUMAN; RFC40;
免疫原
- P35250 RFC2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35250 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K46 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K99 | Ubiquitination | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| R111 | Methylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| K163 | Acetylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| T164 | Phosphorylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| R184 | Methylation | Uniprot | |
| K192 | Acetylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| T200 | Phosphorylation | Uniprot | |
| K208 | Ubiquitination | Uniprot | |
| C255 | S-Nitrosylation | Uniprot | |
| K264 | Ubiquitination | Uniprot | |
| K304 | Acetylation | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K347 | Ubiquitination | Uniprot |
研究背景
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).
Nucleus.
Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can form a complex either with RFC1 or with RAD17. The former interacts with PCNA in the presence of ATP, while the latter has ATPase activity but is not stimulated by PCNA. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival. Interacts with DDX11.
Belongs to the activator 1 small subunits family.
研究領域
· Genetic Information Processing > Replication and repair > DNA replication.
· Genetic Information Processing > Replication and repair > Nucleotide excision repair.
· Genetic Information Processing > Replication and repair > Mismatch repair.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.