SDC1 Antibody - #DF4807
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4807, RRID:AB_2837100.
折りたたみ／展開
CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; syndecan proteoglycan 1; Syndecan-1;
免疫原
- P18827 SDC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P18827 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T61 | O-Glycosylation | Uniprot | |
| T72 | O-Glycosylation | Uniprot | |
| T76 | O-Glycosylation | Uniprot | |
| S77 | O-Glycosylation | Uniprot | |
| T81 | O-Glycosylation | Uniprot | |
| T122 | O-Glycosylation | Uniprot | |
| T164 | O-Glycosylation | Uniprot | |
| S165 | O-Glycosylation | Uniprot | |
| T166 | O-Glycosylation | Uniprot | |
| S171 | O-Glycosylation | Uniprot | |
| T177 | O-Glycosylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| S186 | O-Glycosylation | Uniprot | |
| T188 | O-Glycosylation | Uniprot | |
| T240 | O-Glycosylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| Y299 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| Y309 | Phosphorylation | Uniprot |
研究背景
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Membrane>Single-pass type I membrane protein. Secreted. Secreted>Extracellular exosome.
Note: Shedding of the ectodomain produces a soluble form.
Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity).
Belongs to the syndecan proteoglycan family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
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For Research Use Only.
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