Cytochrome P450 3A7 Antibody - #DF4748
| 製品: | Cytochrome P450 3A7 Antibody |
| カタログ: | DF4748 |
| タンパク質の説明: | Rabbit polyclonal antibody to Cytochrome P450 3A7 |
| アプリケーション: | WB |
| 反応性: | Human, Rat |
| 分子量: | 50 KD; 57kD(Calculated). |
| ユニプロット: | P24462 |
| RRID: | AB_2837102 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4748, RRID:AB_2837102.
折りたたみ／展開
Aryl hydrocarbon hydroxylase; CP37; CP3A7_HUMAN; CYP3A7; CYPIIIA7; Cytochrome P450 3A7; Cytochrome P450, family 3, subfamily A, polypeptide 7; Cytochrome P450, subfamily IIIA, polypeptide 7; Cytochrome P450-HFLA; Flavoprotein linked monooxygenase; Microsomal monooxygenase; P 450(HFL33); P 450111A7; P450 HFLA; Xenobiotic monooxygenase;
免疫原
- P24462 CP3A7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
PTMs - P24462 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y75 | Phosphorylation | Uniprot | |
| S134 | Phosphorylation | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| K406 | Methylation | Uniprot | |
| Y432 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| T485 | Phosphorylation | Uniprot |
研究背景
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes 3beta-hydroxyandrost-5-en-17-one (dehydroepiandrosterone, DHEA), a precursor in the biosynthesis of androgen and estrogen steroid hormones. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1), particularly D-ring hydroxylated estrone at the C16-alpha position. Mainly hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in atRA clearance during fetal development. Also involved in the oxidative metabolism of xenobiotics including anticonvulsants.
Endoplasmic reticulum membrane>Peripheral membrane protein. Microsome membrane>Peripheral membrane protein.
Expressed in fetal liver (at protein level).
Belongs to the cytochrome P450 family.
研究領域
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Metabolism of cofactors and vitamins > Retinol metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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