BAG4 Antibody - #DF4769
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4769, RRID:AB_2837123.
折りたたみ／展開
BAG 4; BAG family molecular chaperone regulator 4; BAG-4; BAG4; BAG4_HUMAN; Bcl 2 associated athanogene 4; Bcl-2-associated athanogene 4; BCL2 associated athanogene 4; Silencer of death domains; SODD;
免疫原
- O95429 BAG4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
PTMs - O95429 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R5 | Methylation | Uniprot | |
| R6 | Methylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| Y9 | Phosphorylation | Uniprot | |
| Y17 | Phosphorylation | Uniprot | |
| R19 | Methylation | Uniprot | |
| R40 | Methylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| R51 | Methylation | Uniprot | |
| R53 | Methylation | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| Y73 | Phosphorylation | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| R108 | Methylation | Uniprot | |
| R110 | Methylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| T181 | Phosphorylation | Uniprot | |
| S184 | Phosphorylation | Uniprot | |
| R185 | Methylation | Uniprot | |
| R201 | Methylation | Uniprot | |
| Y207 | Phosphorylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| T216 | Phosphorylation | Uniprot | |
| R237 | Methylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| Y249 | Phosphorylation | Uniprot | |
| S289 | Phosphorylation | Uniprot | |
| Y302 | Phosphorylation | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| K403 | Ubiquitination | Uniprot |
研究背景
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Cytoplasm.
Ubiquitous.
Binds to the ATPase domain of HSP/HSC70 chaperones. Binds to the death domain of TNFRSF1A in the absence of TNF and thereby prevents binding of adapter molecules such as TRADD or TRAF2. Binds to the death domain of TNFRSF12. Interacts with PRKN.
研究領域
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
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