MATK Antibody - #DF4775
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4775, RRID:AB_2837129.
折りたたみ／展開
CHK; Csk homologous kinase; Csk type protein tyrosine kinase; CTK; DKFZp434N1212; EC 2.7.10.2; Hematopoietic consensus tyrosine lacking kinase; Hematopoietic consensus tyrosine-lacking kinase; HHYLTK; Hydroxyaryl protein kinase; HYL; HYL tyrosine kinase; HYLTK; Leukocyte carboxyl terminal src kinase related; Lsk; matK; MATK_HUMAN; Megakaryocyte associated tyrosine kinase; Megakaryocyte associated tyrosine protein kinase; Megakaryocyte-associated tyrosine-protein kinase; MGC1708; MGC2101; Protein kinase HYL; Tyrosine kinase MATK; Tyrosine protein kinase CTK; Tyrosine-protein kinase CTK; Tyrosylprotein kinase;
免疫原
- P42679 MATK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P42679 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R4 | Methylation | Uniprot | |
| R11 | Methylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| R31 | Methylation | Uniprot | |
| T76 | Phosphorylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| Y87 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| T500 | Phosphorylation | Uniprot | |
| S501 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot |
PTMs - P42679 酵素として
研究背景
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Cytoplasm. Membrane.
Note: In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Expressed in various myeloid cell lines, detected in brain and lung.
Interacts with KIT.
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
研究領域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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