STK10 Antibody - #DF4783
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4783, RRID:AB_2837137.
折りたたみ／展開
LOK; Lymphocyte oriented kinase; Lymphocyte-oriented kinase; PRO2729; Serine threonine protein kinase 10; Serine/threonine-protein kinase 10; STK10; STK10_HUMAN;
免疫原
Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
- O94804 STK10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS
PTMs - O94804 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| R11 | Methylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K65 | Ubiquitination | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| T166 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| T185 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| T195 | Phosphorylation | Uniprot | |
| Y197 | Phosphorylation | Uniprot | |
| T208 | Phosphorylation | Uniprot | |
| T259 | Phosphorylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| S387 | Phosphorylation | Uniprot | |
| T390 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| S392 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| S417 | Phosphorylation | Uniprot | |
| S438 | Phosphorylation | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| S450 | Phosphorylation | Uniprot | |
| S454 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | O94804 (STK10) | Uniprot |
| T459 | Phosphorylation | Uniprot | |
| S469 | Phosphorylation | Uniprot | |
| S485 | Phosphorylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S514 | Phosphorylation | Uniprot | |
| T530 | Phosphorylation | Uniprot | |
| S545 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| K621 | Ubiquitination | Uniprot | |
| S679 | Phosphorylation | Uniprot | |
| T688 | Phosphorylation | Uniprot | |
| K690 | Acetylation | Uniprot | |
| K701 | Ubiquitination | Uniprot | |
| K759 | Ubiquitination | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| S824 | Phosphorylation | Uniprot | |
| K841 | Ubiquitination | Uniprot | |
| S844 | Phosphorylation | Uniprot | |
| K849 | Ubiquitination | Uniprot | |
| S951 | Phosphorylation | Uniprot | |
| T952 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| S954 | Phosphorylation | Uniprot | |
| Y962 | Phosphorylation | Uniprot | |
| S968 | Phosphorylation | Uniprot |
PTMs - O94804 酵素として
研究背景
Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.
Autophosphorylates following homodimerization, leading to activation of the protein.
Cell membrane>Peripheral membrane protein.
Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.
Homodimer; homodimerization is required for activation segment autophosphorylation.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
研究領域
· Organismal Systems > Endocrine system > Progesterone-mediated oocyte maturation.
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