FCGR2C Antibody - #DF4802

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製品: FCGR2C Antibody
カタログ: DF4802
タンパク質の説明: Rabbit polyclonal antibody to FCGR2C
アプリケーション: WB IF/ICC
反応性: Human
分子量: 35 KD; 36kD(Calculated).
ユニプロット: P31995
RRID: AB_2837156

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
FCGR2C Antibody detects endogenous levels of total FCGR2C.
RRID:
AB_2837156
引用形式: Affinity Biosciences Cat# DF4802, RRID:AB_2837156.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD32; CD32A; CD32B; CD32C; CDw32; Fc fragment of IgG low affinity IIa receptor; Fc fragment of IgG low affinity IIa receptor for (CD32); Fc fragment of IgG low affinity IIb receptor; Fc fragment of IgG low affinity IIb receptor for (CD32); Fc fragment of IgG low affinity IIc receptor; Fc fragment of IgG low affinity IIc receptor for (CD32); Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc gamma receptor IIB; Fc gamma receptor IIC; Fc gamma RII a; Fc gamma RII b; Fc gamma RII c; Fc gamma RIIb; Fc gamma RIIc; Fc receptor, IgG, low affinity IIb; Fc-gamma RII-a; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RIIa; FC-gamma-RIIB; Fc-GAMMA-RIIC; Fc[g]RII; FCG2; FCG2A_HUMAN; FcGR; FCGR2; FCGR2A; FCGR2A1; FCGR2B; FCGR2C; Fcgr3; Fcgr3a; FcgRII; Fcr-2; Fcr-3; FcRII a; FCRII; FcRII b; FcRII c; FcRII-a; FcRIIC; IGFR2; IgG Fc receptor II a; IgG Fc receptor II b; IgG Fc receptor II beta; IgG Fc receptor II c; IgG Fc receptor II-a; IgG Fc receptor II-b; IgG Fc receptor II-c; Immunoglobulin G Fc receptor II; Immunoglobulin G Fc receptor II c; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II-a; Low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c; Ly-17; Ly-m20; LyM-1; Lymphocyte antigen 17;

免疫原

免疫原:
Uniprot:

P31995(FCG2C_HUMAN) >>Visit HPA database.

遺伝子(ID):
FCGR2C(9103)
発現特異性:
P31995 FCG2C_HUMAN:

Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

タンパク質配列:
MGILSFLPVLATESDWADCKSPQPWGHMLLWTAVLFLAPVAGTPAAPPKAVLKLEPQWINVLQEDSVTLTCRGTHSPESDSIQWFHNGNLIPTHTQPSYRFKANNNDSGEYTCQTGQTSLSDPVHLTVLSEWLVLQTPHLEFQEGETIVLRCHSWKDKPLVKVTFFQNGKSKKFSRSDPNFSIPQANHSHSGDYHCTGNIGYTLYSSKPVTITVQAPSSSPMGIIVAVVTGIAVAAIVAAVVALIYCRKKRISANSTDPVKAAQFEPPGRQMIAIRKRQPEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN

PTMs - P31995 基板として

Site PTM Type Enzyme
N187 N-Glycosylation
K261 Ubiquitination
K277 Acetylation
Y287 Phosphorylation P43405 (SYK)
Y294 Phosphorylation P51451 (BLK)
T303 Phosphorylation
Y310 Phosphorylation P07948 (LYN) , P43405 (SYK) , P51451 (BLK)

研究背景

機能:

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

PTMs:

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.

細胞の位置付け:

Cytoplasm.

Cell membrane>Single-pass type I membrane protein.

Cell membrane>Single-pass type I membrane protein.

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

タンパク質ファミリー:

Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.

研究領域

· Cellular Processes > Transport and catabolism > Phagosome.   (View pathway)

· Human Diseases > Infectious diseases: Parasitic > Leishmaniasis.

· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.

· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.

· Organismal Systems > Development > Osteoclast differentiation.   (View pathway)

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