KLRC1 Antibody - #DF4808

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製品: KLRC1 Antibody
カタログ: DF4808
タンパク質の説明: Rabbit polyclonal antibody to KLRC1
アプリケーション: WB IHC IF/ICC
反応性: Human
分子量: 28 KD; 26kD(Calculated).
ユニプロット: P26715
RRID: AB_2837159

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
KLRC1 Antibody detects endogenous levels of total KLRC1.
RRID:
AB_2837159
引用形式: Affinity Biosciences Cat# DF4808, RRID:AB_2837159.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C lectin type II protein; CD159 antigen like family member A; CD159 antigen-like family member A; CD159a; CD159a antigen; Killer cell lectin like receptor subfamily C member 1; KLRC1; MGC13374; MGC59791; Natural killer cell lectin; Natural killer cell protein group 2-A1; Natural killer cell receptor NKG2A; Natural killer group protein 2; NK cell receptor A; NKG2 1/B activating NK receptor; NKG2 A; NKG2 A/B activating NK receptor; NKG2 A/B type II integral membrane protein; NKG2 A/NKG2 B type II integral membrane protein; NKG2; NKG2 B; NKG2-1/B activating NK receptor; NKG2-A/B-activating NK receptor; NKG2-A/NKG2-B type II integral membrane protein; NKG2A; NKG2A_HUMAN; NKG2B; rNKG2A;

免疫原

免疫原:
Uniprot:

P26715(NKG2A_HUMAN) >>Visit HPA database.

遺伝子(ID):
KLRC1(3821)
発現特異性:
P26715 NKG2A_HUMAN:

Natural killer cells.

タンパク質配列:
MDNQGVIYSDLNLPPNPKRQQRKPKGNKNSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVGILGIICLILMASVVTIVVIPSTLIQRHNNSSLNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLSIISPSSWIGVFRNSSHHPWVTMNGLAFKHEIKDSDNAELNCAVLQVNRLKSAQCGSSIIYHCKHKL

PTMs - P26715 基板として

Site PTM Type Enzyme
Y8 Phosphorylation
Y40 Phosphorylation
T89 Phosphorylation
S104 Phosphorylation
S105 Phosphorylation
T108 Phosphorylation
T110 Phosphorylation
K195 Acetylation
K199 Acetylation

研究背景

機能:

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

細胞の位置付け:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Natural killer cells.

サブユニット構造:

Can form disulfide-bonded heterodimer with KLRD1. KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex.

研究領域

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

参考文献

1). Identification of a Novel Immune Landscape Signature for Predicting Prognosis and Response of Endometrial Carcinoma to Immunotherapy and Chemotherapy. Frontiers in Cell and Developmental Biology, 2021 (PubMed: 34368124) [IF=5.5]

Application: IHC    Species: Human    Sample: UCEC tumor and the adjacent tissues

FIGURE 4 The mRNA and protein expression level of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (A,B) The mRNA expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (C,D) The protein expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues observed using IHC.

Application: IHC    Species: Human    Sample: UCEC tumor and the adjacent tissues

FIGURE 4 The mRNA and protein expression level of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (A,B) The mRNA expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (C,D) The protein expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues observed using IHC.

Application: IHC    Species: Human    Sample: UCEC tumor and the adjacent tissues

FIGURE 4 The mRNA and protein expression level of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (A,B) The mRNA expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues. (C,D) The protein expression of CCL13 and KLRC1 in UCEC tumor and the adjacent tissues observed using IHC.

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