TNFRSF10D Antibody - #DF4811

(1)  
製品: TNFRSF10D Antibody
カタログ: DF4811
タンパク質の説明: Rabbit polyclonal antibody to TNFRSF10D
アプリケーション: WB IF/ICC
反応性: Human
分子量: 42 KD; 42kD(Calculated).
ユニプロット: Q9UBN6
RRID: AB_2837162

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
TNFRSF10D Antibody detects endogenous levels of total TNFRSF10D.
RRID:
AB_2837162
引用形式: Affinity Biosciences Cat# DF4811, RRID:AB_2837162.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD 264; CD264; DcR 2; DcR2; Decoy receptor 2; Decoy with truncated death domain; OTTHUMP00000123528; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNF-related apoptosis-inducing ligand receptor 4; TNFRSF 10D; TNFRSF10D; TR10D_HUMAN; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAIL-R4; TRAILR4; TRUNDD; Tumor necrosis factor receptor superfamily member 10D; Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain;

免疫原

免疫原:
Uniprot:

Q9UBN6(TR10D_HUMAN) >>Visit HPA database.

遺伝子(ID):
TNFRSF10D(8793)
発現特異性:
Q9UBN6 TR10D_HUMAN:

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

タンパク質配列:
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVESPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL

PTMs - Q9UBN6 基板として

Site PTM Type Enzyme
T134 Phosphorylation
S238 Phosphorylation
Y239 Phosphorylation
K241 Sumoylation
K241 Ubiquitination
S245 Phosphorylation
S263 Phosphorylation
Y284 Phosphorylation
S369 Phosphorylation
Y374 Phosphorylation
S381 Phosphorylation
S384 Phosphorylation

研究背景

機能:

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to it cannot but according to it can induce the NF-kappa-B pathway.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

研究領域

· Cellular Processes > Cell growth and death > Apoptosis.   (View pathway)

· Cellular Processes > Cell growth and death > Necroptosis.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Measles.

· Human Diseases > Infectious diseases: Viral > Influenza A.

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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