ADORA3 Antibody - #DF4851

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製品: ADORA3 Antibody
カタログ: DF4851
タンパク質の説明: Rabbit polyclonal antibody to ADORA3
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 38 KD; 36kD(Calculated).
ユニプロット: P0DMS8
RRID: AB_2837215

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
ADORA3 Antibody detects endogenous levels of total ADORA3.
RRID:
AB_2837215
引用形式: Affinity Biosciences Cat# DF4851, RRID:AB_2837215.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

A3AR; A3R; AA3R; AA3R_HUMAN; AD 026; AD026; Adenosine A3 receptor; Adenosine receptor A3; ADORA 3; ADORA3; ARA3; bA552M11.5; Gpcr2; RP11 552M11.7; TGPCR1;

免疫原

免疫原:
Uniprot:

P0DMS8(AA3R_HUMAN) >>Visit HPA database.

遺伝子(ID):
ADORA3(140)
発現特異性:
P0DMS8 AA3R_HUMAN:

Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

タンパク質配列:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE

PTMs - P0DMS8 基板として

Site PTM Type Enzyme
S213 Phosphorylation

研究背景

機能:

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in the lung and bone. Expressed at lower levels in osteosarcoma tissues (at protein level).

タンパク質ファミリー:

Belongs to the G-protein coupled receptor 1 family.

研究領域

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

参考文献

1). The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain. Animal models and experimental medicine, 2024 (PubMed: 38992885) [IF=3.7]

Application: WB    Species: Mouse    Sample:

FIGURE 2 Multiple electroacupuncture sessions influence the Spinal Adora3 and related enzymes. (A–C) Relative mRNA expression levels of Adora3, CD73, and ADA. (D) Western blot showing protein expression. (E–G) Relative protein expression levels of Adora3, CD73, ADA, and GAPDH. (H) Pearson's correlation analysis of Adora3 and metabolizing enzymes with the nociceptive responses. On days 2EA, 4EA, and 7EA following surgery, samples were obtained from the lumber L4–L6 segments. The data are presented as the means ± SD. Statistical significance was considered at p 

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