MC2R Antibody - #DF4909
| 製品: | MC2R Antibody |
| カタログ: | DF4909 |
| タンパク質の説明: | Rabbit polyclonal antibody to MC2R |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Horse, Sheep, Dog |
| 分子量: | 34 KD; 34kD(Calculated). |
| ユニプロット: | Q01718 |
| RRID: | AB_2837262 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4909, RRID:AB_2837262.
折りたたみ／展開
ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; Melanocortin receptor 2;
免疫原
- Q01718 ACTHR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q01718 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T143 | Phosphorylation | Uniprot | |
| T204 | Phosphorylation | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| S280 | Phosphorylation | Uniprot |
研究背景
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Cell membrane>Multi-pass membrane protein.
Melanocytes and corticoadrenal tissue.
Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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