MC4R Antibody - #DF4984
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4984, RRID:AB_2837333.
折りたたみ／展開
MC4-R; MC4R; MC4R_HUMAN; Melanocortin 4 receptor; Melanocortin receptor 4; MGC126851; MGC138197;
免疫原
- P32245 MC4R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P32245 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y35 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| Y41 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| Y157 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) , P17612 (PRKACA) , P25098 (GRK2) | Uniprot |
| S329 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) , P25098 (GRK2) , P17612 (PRKACA) | Uniprot |
| S330 | Phosphorylation | P25098 (GRK2) , P17612 (PRKACA) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
研究背景
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Cell membrane>Multi-pass membrane protein.
Brain, placental, and gut tissues.
Interacts with ATRNL1 (By similarity). Homodimer; disulfide-linked, also forms higher order oligomers. Interacts with MGRN1, but does not undergo MGRN1-mediated ubiquitination; this interaction competes with GNAS-binding and thus inhibits agonist-induced cAMP production. Interacts with MRAP and MRAP2; these associated factors increase ligand-sensitivity and generation of cAMP.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
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