MRGX1 Antibody - #DF4991
| 製品: | MRGX1 Antibody |
| カタログ: | DF4991 |
| タンパク質の説明: | Rabbit polyclonal antibody to MRGX1 |
| アプリケーション: | IHC IF/ICC |
| 反応性: | Human |
| 分子量: | 36 KD; 36kD(Calculated). |
| ユニプロット: | Q96LB2 |
| RRID: | AB_2837350 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF4991, RRID:AB_2837350.
折りたたみ／展開
GPCR; MAS related gene MRGX1; MAS related GPR member X1; MRGPRX1; MRGX1; SNSR4;
免疫原
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
- Q96LB2 MRGX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
PTMs - Q96LB2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y130 | Phosphorylation | Uniprot |
研究背景
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.
Cell membrane>Multi-pass membrane protein.
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
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