MTLR Antibody - #DF4993

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製品: MTLR Antibody
カタログ: DF4993
タンパク質の説明: Rabbit polyclonal antibody to MTLR
アプリケーション: WB IF/ICC
反応性: Human
分子量: 45 KD; 45kD(Calculated).
ユニプロット: O43193
RRID: AB_2837352

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
MTLR Antibody detects endogenous levels of total MTLR.
RRID:
AB_2837352
引用形式: Affinity Biosciences Cat# DF4993, RRID:AB_2837352.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

G-protein coupled receptor 38; GPR38; MLNR; Motilin receptor; MTLR; MTLR_HUMAN; MTLR1;

免疫原

免疫原:
Uniprot:

O43193(MTLR_HUMAN) >>Visit HPA database.

遺伝子(ID):
MLNR(2862)
発現特異性:
O43193 MTLR_HUMAN:

Expressed only in thyroid, stomach, and bone marrow.

タンパク質配列:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

PTMs - O43193 基板として

Site PTM Type Enzyme
T71 Phosphorylation
T72 Phosphorylation
T73 Phosphorylation
S83 Phosphorylation
R136 Methylation
T296 Phosphorylation
T324 Phosphorylation
S327 Phosphorylation
T402 Phosphorylation
T404 Phosphorylation

研究背景

機能:

Receptor for motilin.

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed only in thyroid, stomach, and bone marrow.

タンパク質ファミリー:

Belongs to the G-protein coupled receptor 1 family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

参考文献

1). Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors. Frontiers in Neuroscience, 2023 (PubMed: 36816129) [IF=4.3]

Application: IF/ICC    Species: Rat    Sample: spinal cord

FIGURE 2 (A) Motilin (MTL) and MTL receptor (MTLR) fluorescence co-labeling in the spinal dorsal horn 2 h after acute incisional pain. (B) Co-labeling of MTLR and β-tubulin III fluorescence in the spinal dorsal horn. MTL (red), MTLR (green), β-tubulin III (violet), and DAPI (blue). Scale bar = 100 μm/20 μm.

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