OPRD1 Antibody - #DF5043
| 製品: | OPRD1 Antibody |
| カタログ: | DF5043 |
| タンパク質の説明: | Rabbit polyclonal antibody to OPRD1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Rabbit |
| 分子量: | 36 KD; 40kD(Calculated). |
| ユニプロット: | P41143 |
| RRID: | AB_2837402 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF5043, RRID:AB_2837402.
折りたたみ／展開
D-OR-1; Delta type opioid receptor; Delta type opioid receptor DOR 1; Delta type opioid receptor DOR1; Delta-type opioid receptor; DOR 1; DOR-1; DOR1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1; OPRD; OPRD_HUMAN; Oprd1;
免疫原
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
- P41143 OPRD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41143 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T161 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| T211 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Q05655 (PRKCD) , Q02156 (PRKCE) , P17252 (PRKCA) | Uniprot |
| T358 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T361 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S363 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
研究背景
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
N-glycosylated.
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
Cell membrane>Multi-pass membrane protein.
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1. Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
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