OPRK1 Antibody - #DF5044
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| 製品: | OPRK1 Antibody |
| カタログ: | DF5044 |
| タンパク質の説明: | Rabbit polyclonal antibody to OPRK1 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse |
| 分子量: | 48 KD; 43kD(Calculated). |
| ユニプロット: | P41145 |
| RRID: | AB_2837403 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF5044, RRID:AB_2837403.
折りたたみ／展開
K-OR-1; Kappa opioid receptor; Kappa type opioid receptor; Kappa-type opioid receptor; KOR 1; KOR; KOR-1; Opiate receptor kappa 1; Opiate receptor, kappa 1; Opioid receptor, kappa 1; OPRK 1; OPRK; OPRK_HUMAN; OPRK1; Oprk2; R21;
免疫原
- P41145 OPRK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41145 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N25 | N-Glycosylation | Uniprot | |
| N39 | N-Glycosylation | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| K349 | Ubiquitination | Uniprot | |
| S358 | Phosphorylation | Q15835 (GRK1) | Uniprot |
| Y369 | Phosphorylation | Calculation | |
| K378 | Ubiquitination | Uniprot |
研究背景
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Cell membrane>Multi-pass membrane protein.
Detected in brain and placenta.
Interacts with SLC9A3R1. Interacts with GABARAPL1.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
参考文献
Application: WB Species: Mouse Sample:
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