OR10A6 Antibody - #DF5047

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製品: OR10A6 Antibody
カタログ: DF5047
タンパク質の説明: Rabbit polyclonal antibody to OR10A6
アプリケーション: WB IF/ICC
反応性: Human
予測: Dog
分子量: 35 KD; 35kD(Calculated).
ユニプロット: Q8NH74
RRID: AB_2837406

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
予測:
Dog(89%)
クローナリティ:
Polyclonal
特異性:
OR10A6 Antibody detects endogenous levels of total OR10A6.
RRID:
AB_2837406
引用形式: Affinity Biosciences Cat# DF5047, RRID:AB_2837406.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

O10A6_HUMAN; Olfactory receptor family 10 subfamily A member 6; Olfactory receptor 10A6; Olfactory receptor OR11-96; OR10A6; OR11 96;

免疫原

免疫原:
Uniprot:

Q8NH74(O10A6_HUMAN) >>Visit HPA database.

遺伝子(ID):
OR10A6(390093)
タンパク質配列:
MERQNQSCVVEFILLGFSNYPELQGQLFVAFLVIYLVTLIGNAIIIVIVSLDQSLHVPMYLFLLNLSVVDLSFSAVIMPEMLVVLSTEKTTISFGGCFAQMYFILLFGGAECFLLGAMAYDRFAAICHPLNYQMIMNKGVFMKLIIFSWALGFMLGTVQTSWVSSFPFCGLNEINHISCETPAVLELACADTFLFEIYAFTGTFLIILVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCAAHLTSVTLFYGTASMTYLQPKSGYSPETKKVMSLSYSLLTPLLNLLIYSLRNSEMKRALMKLWRRRVVLHTI

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
89
Bovine
78
Pig
0
Horse
0
Sheep
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Odorant receptor.

細胞の位置付け:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the G-protein coupled receptor 1 family.

研究領域

· Organismal Systems > Sensory system > Olfactory transduction.

参考文献

1). Distinct sets of olfactory receptors highly expressed in different human tissues evaluated by meta-transcriptome analysis: Association of OR10A6 in skin with keratinization. Frontiers in Cell and Developmental Biology, 2023 (PubMed: 36776557) [IF=5.5]

Application: IF/ICC    Species: Human    Sample: skin

FIGURE 3 Expression of ORs in human keratinocytes and skin. (A) RT-PCR analysis of OR5P2, OR5P3, and OR10A6. GAPDH was used for RNA quality control. M: Marker. (B) Immunofluorescence staining of OR10A6 (green) in human keratinocytes and skin. Cell nuclei appear in blue or white. Magnified sections are indicated by white dashed squares. Bar = 50 μm. (C–F) Immunofluorescence staining of OR10A6 (green) and KRT14, Melan A, Ki-67 or MCSP (red) in human skin. Cell nuclei appear in white. Magnified sections are shown in white dashed squares. Bar = 20 μm. (G) Ratio of OR10A6-positive cells, OR10A6 + Ki-67-positive cells and OR10A6 + MCSP-positive cells counted in skin sections.

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