PAR4 Antibody - #DF5212
| 製品: | PAR4 Antibody |
| カタログ: | DF5212 |
| タンパク質の説明: | Rabbit polyclonal antibody to PAR4 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep |
| 分子量: | 41 KD; 41kD(Calculated). |
| ユニプロット: | Q96RI0 |
| RRID: | AB_2837561 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF5212, RRID:AB_2837561.
折りたたみ／展開
Coagulation factor II (thrombin) receptor like 3; Coagulation factor II receptor like 3; Coagulation factor II receptor-like 3; F2RL3; PAR 4; PAR-4; PAR4; PAR4_HUMAN; protease activated receptor 4; protease activated receptor4; Proteinase activated receptor 4; Proteinase-activated receptor 4; Thrombin receptor like 3; Thrombin receptor-like 3;
免疫原
Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
- Q96RI0 PAR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96RI0 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S366 | Phosphorylation | Uniprot | |
| K367 | Ubiquitination | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| S382 | Phosphorylation | Uniprot |
研究背景
Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Cell membrane>Multi-pass membrane protein.
Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.
Belongs to the G-protein coupled receptor 1 family.
研究領域
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
· Organismal Systems > Immune system > Platelet activation. (View pathway)
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