Cathepsin G Antibody - #AF5167

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製品: Cathepsin G Antibody
カタログ: AF5167
タンパク質の説明: Rabbit polyclonal antibody to Cathepsin G
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 28 kDa; 29kD(Calculated).
ユニプロット: P08311
RRID: AB_2837653

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 100ul $280 在庫あり
 200ul $350 在庫あり

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Cathepsin G Antibody detects endogenous levels of total Cathepsin G.
RRID:
AB_2837653
引用形式: Affinity Biosciences Cat# AF5167, RRID:AB_2837653.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CATG; CATG_HUMAN; Cathepsin G; Cathepsin G precursor; CathepsinG; CG; Ctsg; CTSG protein; MGC23078;

免疫原

免疫原:
Uniprot:

P08311(CATG_HUMAN) >>Visit HPA database.

遺伝子(ID):
CTSG(1511)
タンパク質の説明:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.
タンパク質配列:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL

PTMs - P08311 基板として

Site PTM Type Enzyme
S233 Phosphorylation

研究背景

機能:

Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

細胞の位置付け:

Cell surface.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

(Microbial infection) Interacts with M.tuberculosis protein Rv3364c.

タンパク質ファミリー:

Belongs to the peptidase S1 family.

研究領域

· Cellular Processes > Transport and catabolism > Lysosome.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

· Organismal Systems > Endocrine system > Renin-angiotensin system.   (View pathway)

参考文献

1). Identification of a novel immune gene panel in tongue squamous cell carcinoma. American Journal of Translational Research, 2022 (PubMed: 35702068) [IF=2.2]

Application: IHC    Species: Human    Sample: tumor

Figure 11 Clinical validation for the predicting efficiency of immune-gene panel. A. Relative expression levels of CTSG, CXCL13 and VEGFA in tongue squamous cell carcinoma samples among different T stages in TCGA dataset. B. Relative expression levels of CTSG, CXCL13 and VEGFA in tongue squamous cell carcinoma samples among different N stages in TCGA dataset. C. Clinical validation of VEGFA, CXCL13 and CTSG expression levels in tumor samples at pathologic T1, T3 and T4 stage with the help of IHC staining images. D. Clinical validation of VEGFA, CXCL13, and CTSG expression levels in tumor samples at pathological N0 and N2 stages with the help of IHC staining images. E-G. Clinical validation for accumulation of Th17 cells, CD4+ T cells and CD8+ T cells in TSCC by immunofluorescent staining.

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