CD253 Antibody - #AF5281
製品: | CD253 Antibody |
カタログ: | AF5281 |
タンパク質の説明: | Rabbit polyclonal antibody to CD253 |
アプリケーション: | WB IF/ICC |
反応性: | Human |
予測: | Horse, Dog |
分子量: | 32 kDa; 33kD(Calculated). |
ユニプロット: | P50591 |
RRID: | AB_2837767 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF5281, RRID:AB_2837767.
折りたたみ/展開
Apo 2 ligand; APO 2L; Apo-2 ligand; Apo-2L; APO2L; CD253; CD253 antigen; Chemokine tumor necrosis factor ligand superfamily member 10; Protein TRAIL; TL2; TNF Related Apoptosis Inducing Ligand; TNF related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNF10_HUMAN; TNFSF10; TRAIL; Tumor necrosis factor (ligand) family member 10; Tumor Necrosis Factor (ligand) Superfamily Member 10; Tumor necrosis factor apoptosis inducing ligand splice variant delta; Tumor necrosis factor ligand superfamily member 10;
免疫原
- P50591 TNF10_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P50591 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K106 | Ubiquitination | Uniprot | |
S133 | Phosphorylation | Uniprot | |
T135 | Phosphorylation | Uniprot | |
Y213 | Phosphorylation | Uniprot | |
T214 | Phosphorylation | Uniprot | |
S225 | Phosphorylation | Uniprot |
研究背景
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Tyrosine phosphorylated by PKDCC/VLK.
Cell membrane>Single-pass type II membrane protein. Secreted.
Note: Exists both as membrane-bound and soluble form.
Widespread; most predominant in spleen, lung and prostate.
Homotrimer. One TNFSF10 homotrimer interacts with three TNFSF10A mononers. One TNFSF10 homotrimer interacts with three TNFSF10B mononers.
Belongs to the tumor necrosis factor family.
研究領域
· Cellular Processes > Cell growth and death > Apoptosis. (View pathway)
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > Influenza A.
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
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