HSP105 Antibody - #AF5338
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF5338, RRID:AB_2837823.
折りたたみ／展開
Antigen NY CO 25; Antigen NY-CO-25; DKFZp686M05240; Heat shock 105kD alpha; Heat shock 105kD; Heat shock 105kD beta; Heat shock 105kDa protein 1; Heat shock 105kDa protein; Heat shock 105kDa/110kDa protein 1; Heat shock 110 kDa protein; Heat shock 110kDa protein; Heat shock protein 105 kDa; HS105_HUMAN; HSP105; HSP105A; HSP105B; HSP110; HSPH 1; Hsph1; KIAA0201; NY CO 25;
免疫原
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
- Q92598 HS105_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAMLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q92598 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| R33 | Methylation | Uniprot | |
| S43 | Phosphorylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| K68 | Acetylation | Uniprot | |
| K68 | Methylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| Y89 | Phosphorylation | Uniprot | |
| K95 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K126 | Ubiquitination | Uniprot | |
| S132 | Phosphorylation | Uniprot | |
| T138 | Phosphorylation | Uniprot | |
| T149 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K194 | Acetylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K234 | Acetylation | Uniprot | |
| K234 | Ubiquitination | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K249 | Acetylation | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| R265 | Methylation | Uniprot | |
| K272 | Acetylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| K274 | Acetylation | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| S304 | Phosphorylation | Uniprot | |
| Y322 | Phosphorylation | Uniprot | |
| K351 | Ubiquitination | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K360 | Acetylation | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| T365 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K388 | Methylation | Uniprot | |
| K388 | Ubiquitination | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| K430 | Acetylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K475 | Ubiquitination | Uniprot | |
| T486 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| T494 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S554 | Phosphorylation | Uniprot | |
| S557 | Phosphorylation | Uniprot | |
| T561 | Phosphorylation | Uniprot | |
| S562 | Phosphorylation | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K590 | Ubiquitination | Uniprot | |
| Y614 | Phosphorylation | Uniprot | |
| K626 | Ubiquitination | Uniprot | |
| K635 | Ubiquitination | Uniprot | |
| Y641 | Phosphorylation | Uniprot | |
| Y643 | Phosphorylation | Uniprot | |
| K648 | Ubiquitination | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| T670 | Phosphorylation | Uniprot | |
| T672 | Phosphorylation | Uniprot | |
| Y677 | Phosphorylation | Uniprot | |
| Y688 | Phosphorylation | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| K697 | Ubiquitination | Uniprot | |
| T700 | Phosphorylation | Uniprot | |
| K703 | Ubiquitination | Uniprot | |
| K714 | Ubiquitination | Uniprot | |
| K749 | Ubiquitination | Uniprot | |
| K772 | Ubiquitination | Uniprot | |
| K790 | Ubiquitination | Uniprot | |
| K804 | Ubiquitination | Uniprot | |
| K806 | Ubiquitination | Uniprot | |
| S809 | Phosphorylation | Uniprot | |
| K811 | Acetylation | Uniprot | |
| K811 | Ubiquitination | Uniprot | |
| T815 | Phosphorylation | Uniprot | |
| K823 | Ubiquitination | Uniprot | |
| K824 | Ubiquitination | Uniprot | |
| S852 | Phosphorylation | Uniprot |
研究背景
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
Cytoplasm.
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Interacts with HSPA8/HSC70 (By similarity). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD).
Belongs to the heat shock protein 70 family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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