BVES Antibody - #DF6019
| 製品: | BVES Antibody |
| カタログ: | DF6019 |
| タンパク質の説明: | Rabbit polyclonal antibody to BVES |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 41kDa; 41kD(Calculated). |
| ユニプロット: | Q8NE79 |
| RRID: | AB_2837994 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6019, RRID:AB_2837994.
折りたたみ／展開
Blood vessel epicardial substance; Bves; hBVES; MGC42413; POP 1; POP1; POPD1_HUMAN; POPDC 1; POPDC1; Popeye domain containing 1; Popeye domain containing protein 1; Popeye domain-containing protein 1; Popeye protein 1;
免疫原
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
- Q8NE79 POPD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8NE79 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y3 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K122 | Acetylation | Uniprot | |
| Y194 | Phosphorylation | Uniprot |
研究背景
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
Lateral cell membrane. Cell junction>Tight junction. Membrane>Multi-pass membrane protein. Cell membrane>Sarcolemma. Membrane>Caveola.
Note: Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells.
Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (By similarity). Interacts with CAV3 (By similarity).
Belongs to the popeye family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Tight junction. (View pathway)
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