SMNDC1 Antibody - #DF6121
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6121, RRID:AB_2838088.
折りたたみ／展開
30 kDa splicing factor SMNrp; MGC106917; MGC112663; SMN related protein; SMN-related protein; smndc1; SMNR; SPF30; SPF30_HUMAN; Splicing factor 30, survival of motor neuron-related; Survival motor neuron domain containing 1; Survival motor neuron domain containing protein 1; Survival motor neuron domain-containing protein 1; Survival of motor neuron related splicing factor 30; Survival of motor neuron-related-splicing factor 30;
免疫原
Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.
- O75940 SPF30_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O75940 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K13 | Ubiquitination | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| T52 | Phosphorylation | Uniprot | |
| T57 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| T70 | Phosphorylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| R184 | Methylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| S204 | Phosphorylation | Uniprot | |
| T206 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| K219 | Acetylation | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| Y224 | Phosphorylation | Uniprot | |
| T227 | Phosphorylation | Uniprot | |
| K229 | Ubiquitination | Uniprot |
研究背景
Necessary for spliceosome assembly. Overexpression causes apoptosis.
Nucleus speckle. Nucleus>Cajal body.
Note: Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.
Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.
Associates with spliceosomes. Associates with U4/U5/U6 tri-snRNP and with U2 snRNP.
The Tudor domain mediates association with dimethylarginines, which are common in snRNP proteins.
Belongs to the SMN family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
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