PPIA Antibody - #DF6175
| 製品: | PPIA Antibody |
| カタログ: | DF6175 |
| タンパク質の説明: | Rabbit polyclonal antibody to PPIA |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit |
| 分子量: | 18kDa; 18kD(Calculated). |
| ユニプロット: | P62937 |
| RRID: | AB_2838142 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6175, RRID:AB_2838142.
折りたたみ／展開
Cyclophilin A; Cyclophilin; CyclophilinA; Cyclosporin A binding protein; Cyclosporin A-binding protein; CYPA; CYPH; Epididymis secretory sperm binding protein Li 69p; HEL S 69p; MGC117158; MGC12404; MGC23397; Peptidyl prolyl cis trans isomerase A; Peptidyl-prolyl cis-trans isomerase A; Peptidylprolyl isomerase A (cyclophilin A); Peptidylprolyl isomerase A; PPIA; PPIA protein; PPIA_HUMAN; PPIase A; Rotamase A; RotamaseA; T cell cyclophilin;
免疫原
- P62937 PPIA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P62937 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| V2 | Acetylation | Uniprot | |
| T5 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| K28 | Acetylation | Uniprot | |
| K28 | Ubiquitination | Uniprot | |
| K31 | Acetylation | Uniprot | |
| K31 | Sumoylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K44 | Acetylation | Uniprot | |
| K44 | Sumoylation | Uniprot | |
| K44 | Ubiquitination | Uniprot | |
| Y48 | Phosphorylation | Uniprot | |
| K49 | Acetylation | Uniprot | |
| K49 | Methylation | Uniprot | |
| K49 | Sumoylation | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| C52 | S-Nitrosylation | Uniprot | |
| T68 | Phosphorylation | Uniprot | |
| K76 | Acetylation | Uniprot | |
| K76 | Sumoylation | Uniprot | |
| K76 | Ubiquitination | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| Y79 | Phosphorylation | Uniprot | |
| K82 | Acetylation | Uniprot | |
| K82 | Sumoylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K91 | Acetylation | Uniprot | |
| K91 | Methylation | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T107 | Phosphorylation | Uniprot | |
| S110 | Phosphorylation | Uniprot | |
| T116 | Phosphorylation | Uniprot | |
| K118 | Acetylation | Uniprot | |
| K118 | Sumoylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| K125 | Acetylation | Uniprot | |
| K125 | Methylation | Uniprot | |
| K125 | Sumoylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K131 | Acetylation | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| K133 | Acetylation | Uniprot | |
| K133 | Sumoylation | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K151 | Ubiquitination | Uniprot | |
| K155 | Acetylation | Uniprot | |
| K155 | Sumoylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| C161 | S-Nitrosylation | Uniprot |
研究背景
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Acetylation at Lys-125 markedly inhibits catalysis of cis to trans isomerization and stabilizes cis rather than trans forms of the HIV-1 capsid. PPIA acetylation also antagonizes the immunosuppressive effects of cyclosporine by inhibiting the sequential steps of cyclosporine binding and calcineurin inhibition.
Cytoplasm. Secreted.
Note: Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.
Interacts with protein phosphatase PPP3CA/calcineurin A.
(Microbial infection) Interacts with HIV-1 capsid protein.
Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
研究領域
· Cellular Processes > Cell growth and death > Necroptosis. (View pathway)
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