SERPINA3 Antibody - #DF6185
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| 製品: | SERPINA3 Antibody |
| カタログ: | DF6185 |
| タンパク質の説明: | Rabbit polyclonal antibody to SERPINA3 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Rabbit |
| 分子量: | 48kDa; 48kD(Calculated). |
| ユニプロット: | P01011 |
| RRID: | AB_2838151 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6185, RRID:AB_2838151.
折りたたみ／展開
SERPINA3; AACT; AACT_HUMAN; ACT; Alpha-1-antichymotrypsin His-Pro-less; Antichymotrypsin; Cell growth inhibiting gene 24/25 protein; Cell growth-inhibiting gene 24/25 protein; GIG24; GIG25; Growth inhibiting protein 24; Growth inhibiting protein 25; MGC88254; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase, antitrypsin) member 3; Serine (or cysteine) proteinase inhibitor clade A member 3; Serine proteinase inhibitor clade A member 3; Serpin A3; Serpin family A member 3; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3; SERPINA3;
免疫原
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
- P01011 AACT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALFILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P01011 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N33 | N-Glycosylation | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| N93 | N-Glycosylation | Uniprot | |
| N106 | N-Glycosylation | Uniprot | |
| N127 | N-Glycosylation | Uniprot | |
| K158 | Acetylation | Uniprot | |
| K177 | Acetylation | Uniprot | |
| N186 | N-Glycosylation | Uniprot | |
| K191 | Acetylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| T203 | Phosphorylation | Uniprot | |
| K235 | Acetylation | Uniprot | |
| K236 | Acetylation | Uniprot | |
| K237 | Acetylation | Uniprot | |
| C261 | S-Nitrosylation | Uniprot | |
| N271 | N-Glycosylation | Uniprot | |
| S273 | Phosphorylation | Uniprot | |
| T295 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| T347 | O-Glycosylation | Uniprot | |
| T347 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K416 | Acetylation | Uniprot | |
| K421 | Acetylation | Uniprot |
研究背景
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
N- and O-glycosylated.
Secreted.
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Interacts with DNAJC1.
The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Belongs to the serpin family.
参考文献
Application: WB Species: Human Sample:
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