MTAP Antibody - #DF6197
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6197, RRID:AB_2838163.
折りたたみ／展開
5' methylthioadenosine phosphorylase; 5''-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL 249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAP_HUMAN; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase;
免疫原
- Q13126 MTAP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q13126 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S3 | Phosphorylation | Uniprot | |
| T5 | Phosphorylation | Uniprot | |
| T6 | Phosphorylation | Uniprot | |
| T7 | Phosphorylation | Uniprot | |
| T8 | Phosphorylation | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| K40 | Ubiquitination | Uniprot | |
| K49 | Ubiquitination | Uniprot | |
| R60 | Methylation | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| C131 | S-Nitrosylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| T188 | Phosphorylation | Uniprot | |
| R235 | Methylation | Uniprot | |
| K248 | Ubiquitination | Uniprot |
研究背景
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Cytoplasm. Nucleus.
Ubiquitously expressed.
Homotrimer.
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
研究領域
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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