HADH Antibody - #DF6221
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6221, RRID:AB_2838187.
折りたたみ／展開
3 hydroxyacyl Coenzyme A dehydrogenase; HAD; HADH; HADH1; HADHSC; HADHSC, formerly; HADSC, formerly; HCDH; HCDH_HUMAN; HHF4; Hydroxyacyl CoA dehydrogenase; Hydroxyacyl-coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; L 3 hydroxyacyl Coenzyme A dehydrogenase short chain; M SCHAD; Medium and short chain L 3 hydroxyacyl coenzyme A dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; MGC8392; mitochondrial; MSCHAD; OTTHUMP00000162626; OTTHUMP00000219688; SCHAD; SCHAD, formerly; Short chain 3 hydroxyacyl CoA dehydrogenase mitochondrial; short chain 3-hydroxyacyl-coa dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase;
免疫原
- Q16836 HCDH_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIVDGWHEMDAENPLHQPSPSLNKLVAENKFGKKTGEGFYKYK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q16836 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| R75 | Methylation | Uniprot | |
| K76 | Acetylation | Uniprot | |
| K80 | Acetylation | Uniprot | |
| K81 | Acetylation | Uniprot | |
| K87 | Acetylation | Uniprot | |
| K87 | Ubiquitination | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K132 | Acetylation | Uniprot | |
| K179 | Acetylation | Uniprot | |
| K185 | Acetylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K192 | Acetylation | Uniprot | |
| K192 | Ubiquitination | Uniprot | |
| T193 | Phosphorylation | Uniprot | |
| S196 | Phosphorylation | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K212 | Acetylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| T214 | Phosphorylation | Uniprot | |
| Y226 | Phosphorylation | Uniprot | |
| Y234 | Phosphorylation | Uniprot | |
| K241 | Acetylation | Uniprot | |
| K241 | Ubiquitination | Uniprot | |
| K249 | Acetylation | Uniprot | |
| Y264 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K304 | Acetylation | Uniprot | |
| K312 | Acetylation | Uniprot | |
| K312 | Methylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| Y313 | Phosphorylation | Uniprot |
研究背景
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity).
Mitochondrion matrix.
Expressed in liver, kidney, pancreas, heart and skeletal muscle.
Homodimer.
Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
研究領域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Amino acid metabolism > Lysine degradation.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Carbohydrate metabolism > Butanoate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
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