MAGED1 Antibody - #DF6235
| 製品: | MAGED1 Antibody |
| カタログ: | DF6235 |
| タンパク質の説明: | Rabbit polyclonal antibody to MAGED1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Rabbit, Dog |
| 分子量: | 86kDa; 86kD(Calculated). |
| ユニプロット: | Q9Y5V3 |
| RRID: | AB_2838201 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6235, RRID:AB_2838201.
折りたたみ／展開
DLXIN 1; MAGD1_HUMAN; MAGE D1 antigen; MAGE tumor antigen CCF; MAGE-D1 antigen; Maged1; Melanoma antigen family D 1; Melanoma associated antigen D1; Melanoma-associated antigen D1; Neurotrophin receptor interacting MAGE homolog; Neurotrophin receptor-interacting MAGE homolog; NRAGE; PP2250;
免疫原
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
- Q9Y5V3 MAGD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9Y5V3 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S76 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| Y92 | Phosphorylation | Uniprot | |
| S95 | Phosphorylation | Uniprot | |
| K101 | Acetylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| K109 | Acetylation | Uniprot | |
| K109 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| Y126 | Phosphorylation | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K147 | Methylation | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| T160 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| T179 | Phosphorylation | Uniprot | |
| K182 | Ubiquitination | Uniprot | |
| K189 | Ubiquitination | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot | |
| T316 | Phosphorylation | Uniprot | |
| S322 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| K493 | Ubiquitination | Uniprot | |
| Y505 | Phosphorylation | Uniprot | |
| K522 | Ubiquitination | Uniprot | |
| K523 | Ubiquitination | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K555 | Ubiquitination | Uniprot | |
| S578 | Phosphorylation | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| R604 | Methylation | Uniprot | |
| K605 | Ubiquitination | Uniprot | |
| K613 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| Y630 | Phosphorylation | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| T642 | Phosphorylation | Uniprot | |
| S643 | Phosphorylation | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot |
研究背景
Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Cytoplasm. Cell membrane>Peripheral membrane protein. Nucleus.
Note: Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.
研究領域
· Organismal Systems > Nervous system > Neurotrophin signaling pathway. (View pathway)
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