BCL2L13 Antibody - #DF6248

(1)  
製品: BCL2L13 Antibody
カタログ: DF6248
タンパク質の説明: Rabbit polyclonal antibody to BCL2L13
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 53kDa; 53kD(Calculated).
ユニプロット: Q9BXK5
RRID: AB_2838214

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MSDS
説明書
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(88%), Bovine(88%), Horse(100%), Sheep(88%), Rabbit(100%), Dog(100%), Chicken(100%)
クローナリティ:
Polyclonal
特異性:
BCL2L13 Antibody detects endogenous levels of total BCL2L13.
RRID:
AB_2838214
引用形式: Affinity Biosciences Cat# DF6248, RRID:AB_2838214.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Apoptosis facilitator; B2L13_HUMAN; Bcl 2 like 13; Bcl 2 like 13 protein; Bcl-2-like protein 13; Bcl-rambo; BCL2 like 13 apoptosis facilitator; BCL2 like 13; Bcl2 like 13 protein; Bcl2-L-13; BCL2L13; MIL 1; MIL1; MIL1 protein; Protein Mil1;

免疫原

免疫原:
Uniprot:

Q9BXK5(B2L13_HUMAN) >>Visit HPA database.

遺伝子(ID):
BCL2L13(23786)
発現特異性:
Q9BXK5 B2L13_HUMAN:

Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.

タンパク質の説明:
Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.
タンパク質配列:
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQLDIASQSLDQEILLKVKTEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMEDCLAHLGEKVSQELKEPLHKALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQEPLSALLQFGVTYLEDYSAEYIIQQGGWGTVFSLESEEEEYPGITAEDSNDIYILPSDNSGQVSPPESPTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSNGAGEKSENNSSNSDIVHVEKEEVPEGMEEAAVASVVLPARELQEALPEAPAPLLPHITATSLLGTREPDTEVITVEKSSPATSLFVELDEEEVKAATTEPTEVEEVVPALEPTETLLSEKEINAREESLVEELSPASEKKPVPPSEGKSRLSPAGEMKPMPLSEGKSILLFGGAAAVAILAVAIGVALALRKK

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Dog
100
Chicken
100
Rabbit
100
Pig
88
Bovine
88
Sheep
88
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9BXK5 基板として

Site PTM Type Enzyme
S3 Phosphorylation
S37 Phosphorylation
S38 Phosphorylation
K60 Ubiquitination
K68 Ubiquitination
K72 Ubiquitination
K110 Ubiquitination
K116 Ubiquitination
T168 Phosphorylation
S259 Phosphorylation
S261 Phosphorylation
S270 Phosphorylation
S275 Phosphorylation
S288 Phosphorylation
S291 Phosphorylation
S298 Phosphorylation
S302 Phosphorylation
S303 Phosphorylation
S305 Phosphorylation
S326 Phosphorylation
T352 Phosphorylation
S370 Phosphorylation
S371 Phosphorylation
T374 Phosphorylation
S375 Phosphorylation
S410 Phosphorylation
K412 Ubiquitination
S420 Phosphorylation
S426 Phosphorylation
S429 Phosphorylation
S437 Phosphorylation
K440 Ubiquitination
S441 Phosphorylation
S444 Phosphorylation
K450 Ubiquitination

研究背景

機能:

May promote the activation of caspase-3 and apoptosis.

細胞の位置付け:

Mitochondrion membrane>Single-pass membrane protein. Nucleus.

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.

サブユニット構造:

Monomer.

タンパク質ファミリー:

Belongs to the Bcl-2 family.

研究領域

· Human Diseases > Infectious diseases: Bacterial > Legionellosis.

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