Emerin Antibody - #DF6266
| 製品: | Emerin Antibody |
| カタログ: | DF6266 |
| タンパク質の説明: | Rabbit polyclonal antibody to Emerin |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog |
| 分子量: | 29kDa; 29kD(Calculated). |
| ユニプロット: | P50402 |
| RRID: | AB_2838232 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6266, RRID:AB_2838232.
折りたたみ／展開
EDMD; Emd; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA;
免疫原
- P50402 EMD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRLSPPSSSAASSYSFSDLNSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQSVTSFPDADAFHHQVHDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLSYYPTSSSTSFMSSSSSSSSWLTRRAIRPENRAPGAGLGQDRQVPLWGQLLLFLVFVIVLFFIYHFMQAEEGNPF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P50402 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| T10 | Phosphorylation | Uniprot | |
| Y19 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| S29 | Phosphorylation | Uniprot | |
| Y34 | Phosphorylation | Uniprot | |
| K37 | Ubiquitination | Uniprot | |
| Y41 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| T43 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| S52 | Phosphorylation | Uniprot | |
| S53 | O-Glycosylation | Uniprot | |
| S53 | Phosphorylation | Uniprot | |
| S54 | O-Glycosylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| Y59 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) | Uniprot |
| S60 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| T67 | Phosphorylation | Uniprot | |
| Y74 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| K78 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| Y85 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| S87 | O-Glycosylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| Y90 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| Y94 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) | Uniprot |
| Y95 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) | Uniprot |
| S98 | Phosphorylation | Uniprot | |
| Y99 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) | Uniprot |
| T101 | Phosphorylation | Uniprot | |
| R103 | Methylation | Uniprot | |
| T104 | Phosphorylation | Uniprot | |
| Y105 | Phosphorylation | P12931 (SRC) , P00519 (ABL1) | Uniprot |
| S110 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| T122 | Phosphorylation | Uniprot | |
| S123 | Phosphorylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| S143 | Phosphorylation | Uniprot | |
| Y155 | Phosphorylation | P00519 (ABL1) | Uniprot |
| S159 | Phosphorylation | Uniprot | |
| Y161 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| S163 | Phosphorylation | Uniprot | |
| T165 | Phosphorylation | Uniprot | |
| Y167 | Phosphorylation | P00519 (ABL1) , P12931 (SRC) | Uniprot |
| S171 | O-Glycosylation | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| S173 | O-Glycosylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| S176 | Phosphorylation | Uniprot | |
| S180 | Phosphorylation | Uniprot | |
| Y181 | Phosphorylation | P12931 (SRC) | Uniprot |
| Y182 | Phosphorylation | P12931 (SRC) | Uniprot |
| S189 | Phosphorylation | Uniprot |
研究背景
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
Nucleus inner membrane>Single-pass membrane protein>Nucleoplasmic side. Nucleus outer membrane.
Note: Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Skeletal muscle, heart, colon, testis, ovary and pancreas.
Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane. Interacts with SUN1 and SUN2 (By similarity). Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin. Interacts with TMEM201.
研究領域
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
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