RALBP1 Antibody - #DF6274
製品: | RALBP1 Antibody |
カタログ: | DF6274 |
タンパク質の説明: | Rabbit polyclonal antibody to RALBP1 |
アプリケーション: | WB IHC |
反応性: | Human, Mouse, Rat |
予測: | Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus |
分子量: | 76kDa; 76kD(Calculated). |
ユニプロット: | Q15311 |
RRID: | AB_2838240 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6274, RRID:AB_2838240.
折りたたみ/展開
RLIP1; 76 kDa Ral-interacting protein; 76-kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; Ral-interacting protein 1, 76-KD; RalA-binding protein 1; RalBP1; RBP1_HUMAN; RIP1; RLIP1; RLIP76;
免疫原
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
- Q15311 RBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15311 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
T2 | Acetylation | Uniprot | |
T9 | Phosphorylation | Uniprot | |
S11 | Phosphorylation | Uniprot | |
S13 | Phosphorylation | Uniprot | |
T25 | Phosphorylation | Uniprot | |
T27 | Phosphorylation | Uniprot | |
S29 | Phosphorylation | Uniprot | |
S30 | Phosphorylation | Uniprot | |
S34 | Phosphorylation | Uniprot | |
T36 | Phosphorylation | Uniprot | |
T44 | Phosphorylation | Uniprot | |
S48 | Phosphorylation | Uniprot | |
S62 | Phosphorylation | Uniprot | |
T82 | Phosphorylation | Uniprot | |
Y85 | Phosphorylation | Uniprot | |
S92 | Phosphorylation | Uniprot | |
S93 | Phosphorylation | Uniprot | |
S99 | Phosphorylation | Uniprot | |
S116 | Phosphorylation | Uniprot | |
S118 | Phosphorylation | P17252 (PRKCA) | Uniprot |
S151 | Phosphorylation | Uniprot | |
K152 | Ubiquitination | Uniprot | |
K161 | Ubiquitination | Uniprot | |
Y219 | Phosphorylation | Uniprot | |
S234 | Phosphorylation | Uniprot | |
S252 | Phosphorylation | Uniprot | |
T253 | Phosphorylation | Uniprot | |
K268 | Ubiquitination | Uniprot | |
Y270 | Phosphorylation | Uniprot | |
T280 | Phosphorylation | Uniprot | |
K281 | Ubiquitination | Uniprot | |
T297 | Phosphorylation | P17252 (PRKCA) | Uniprot |
K299 | Ubiquitination | Uniprot | |
S353 | Phosphorylation | P17252 (PRKCA) | Uniprot |
K421 | Ubiquitination | Uniprot | |
K454 | Ubiquitination | Uniprot | |
S461 | Phosphorylation | Uniprot | |
S463 | Phosphorylation | Uniprot | |
K469 | Ubiquitination | Uniprot | |
S509 | Phosphorylation | P17252 (PRKCA) | Uniprot |
K600 | Ubiquitination | Uniprot | |
S645 | Phosphorylation | Uniprot | |
S647 | Phosphorylation | Uniprot |
研究背景
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Membrane>Peripheral membrane protein.
Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.
研究領域
· Environmental Information Processing > Signal transduction > Ras signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Pancreatic cancer. (View pathway)
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