RRM1 Antibody - #DF6286
(1)
(4)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6286, RRID:AB_2838252.
折りたたみ／展開
R1; Ribonucleoside diphosphate reductase large subunit; Ribonucleoside diphosphate reductase M1 chain; Ribonucleoside diphosphate reductase subunit M1; Ribonucleoside reductase, large subunit; Ribonucleoside-diphosphate reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1; Ribonucleotide reductase M1 polypeptide; Ribonucleotide reductase R1 subunit; Ribonucleotide reductase, M1 subunit; RIR 1; RIR1; RIR1_HUMAN; RR 1; RR1; RRM 1; RRM1;
免疫原
- P23921 RIR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCSLENRDECLMCGS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23921 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K5 | Ubiquitination | Uniprot | |
| K17 | Acetylation | Uniprot | |
| K17 | Ubiquitination | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| Y74 | Phosphorylation | Uniprot | |
| R80 | Methylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| Y102 | Phosphorylation | Uniprot | |
| Y104 | Phosphorylation | Uniprot | |
| K111 | Ubiquitination | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| S133 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| Y232 | Phosphorylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| S253 | Phosphorylation | Uniprot | |
| K320 | Methylation | Uniprot | |
| K320 | Ubiquitination | Uniprot | |
| K369 | Ubiquitination | Uniprot | |
| K376 | Acetylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K414 | Ubiquitination | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| T422 | Phosphorylation | Uniprot | |
| K424 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K479 | Ubiquitination | Uniprot | |
| Y485 | Phosphorylation | Uniprot | |
| Y486 | Phosphorylation | Uniprot | |
| K496 | Acetylation | Uniprot | |
| K496 | Ubiquitination | Uniprot | |
| K548 | Ubiquitination | Uniprot | |
| Y553 | Phosphorylation | Uniprot | |
| T555 | Phosphorylation | Uniprot | |
| Y556 | Phosphorylation | Uniprot | |
| S559 | Phosphorylation | Uniprot | |
| K563 | Ubiquitination | Uniprot | |
| K582 | Ubiquitination | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| K590 | Ubiquitination | Uniprot | |
| T604 | Phosphorylation | Uniprot | |
| S631 | Phosphorylation | Uniprot | |
| K643 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| K677 | Ubiquitination | Uniprot | |
| K681 | Ubiquitination | Uniprot | |
| K689 | Ubiquitination | Uniprot | |
| K693 | Ubiquitination | Uniprot | |
| Y726 | Phosphorylation | Uniprot | |
| K729 | Ubiquitination | Uniprot | |
| K733 | Ubiquitination | Uniprot | |
| Y738 | Phosphorylation | Uniprot | |
| T751 | Phosphorylation | Uniprot | |
| K754 | Ubiquitination | Uniprot | |
| K762 | Ubiquitination | Uniprot | |
| K765 | Ubiquitination | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| T774 | Phosphorylation | Uniprot | |
| S780 | Phosphorylation | Uniprot | |
| S792 | Phosphorylation | Uniprot |
研究背景
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Cytoplasm.
Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B. Interacts with AHCYL1 which inhibits its activity.
Belongs to the ribonucleoside diphosphate reductase large chain family.
研究領域
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of other amino acids > Glutathione metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
参考文献
Application: WB Species: human Sample:
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.