ECI1 Antibody - #DF6343

(1)  
製品: ECI1 Antibody
カタログ: DF6343
タンパク質の説明: Rabbit polyclonal antibody to ECI1
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Horse, Sheep, Rabbit, Chicken, Xenopus
分子量: 33kDa; 33kD(Calculated).
ユニプロット: P42126
RRID: AB_2838307

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Horse(100%), Sheep(89%), Rabbit(92%), Chicken(92%), Xenopus(92%)
クローナリティ:
Polyclonal
特異性:
ECI1 Antibody detects endogenous levels of total ECI1.
RRID:
AB_2838307
引用形式: Affinity Biosciences Cat# DF6343, RRID:AB_2838307.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

2-trans-enoyl-CoA isomerase; 3; 3,2 trans enoyl Coenzyme A isomerase; 3,2 trans-enoyl-CoA isomerase; 3,2-trans-enoyl-CoA isomerase, mitochondrial; Acetylene allene isomerase; D2-enoyl-CoA isomerase; D3; D3,D2 enoyl CoA isomerase; DCI; DCI protein; delta(2)-enoyl-CoA isomerase; Delta(3); Delta(3),Delta(2) enoyl CoA isomerase; Delta3, delta2 enoyl CoA isomerase; Dodecenoyl CoA delta Isomerase; Dodecenoyl CoA isomerase; Dodecenoyl Coenzyme A delta isomerase; Dodecenoyl Coenzyme A delta isomerase (3,2 trans enoyl Coenzyme A isomerase); Dodecenoyl Coenzyme A delta isomerase 3,2 trans enoyl Coenzyme A isomerase, isoform CRA a; Dodecenoyl-CoA isomerase; ECI1; ECI1_HUMAN; Enoyl-CoA delta isomerase 1; enoyl-CoA delta isomerase 1, mitochondrial; mitochondrial;

免疫原

免疫原:
Uniprot:

P42126(ECI1_HUMAN) >>Visit HPA database.

遺伝子(ID):
ECI1(1632)
タンパク質の説明:
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
タンパク質配列:
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Xenopus
92
Chicken
92
Rabbit
92
Sheep
89
Pig
78
Bovine
67
Dog
67
Zebrafish
67
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P42126 基板として

Site PTM Type Enzyme
K61 Ubiquitination
K89 Acetylation
R171 Methylation
S279 Phosphorylation
S282 Phosphorylation
K283 Acetylation
K283 Ubiquitination
S285 Phosphorylation
K288 Acetylation
K288 Ubiquitination

研究背景

機能:

Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.

細胞の位置付け:

Mitochondrion matrix.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homotrimer.

タンパク質ファミリー:

Belongs to the enoyl-CoA hydratase/isomerase family.

研究領域

· Metabolism > Lipid metabolism > Fatty acid degradation.

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