STIP1 Antibody - #DF6351
製品: | STIP1 Antibody |
カタログ: | DF6351 |
タンパク質の説明: | Rabbit polyclonal antibody to STIP1 |
アプリケーション: | WB IHC |
反応性: | Human, Mouse, Rat |
予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
分子量: | 63kDa; 63kD(Calculated). |
ユニプロット: | P31948 |
RRID: | AB_2838315 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6351, RRID:AB_2838315.
折りたたみ/展開
Epididymis secretory sperm binding protein Li 94n; HEL S 94n; Hop; Hsc70/Hsp90 organizing protein; Hsc70/Hsp90-organizing protein; IEF SSP 3521; NY REN 11 antigen; P60; Renal carcinoma antigen NY-REN-11; STI1; STI1L; STIP1; STIP1_HUMAN; Stress induced phosphoprotein 1; Stress-induced-phosphoprotein 1; Transformation sensitive protein IEF SSP 3521; Transformation-sensitive protein IEF SSP 3521;
免疫原
- P31948 STIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLIAIR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P31948 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
M1 | Acetylation | Uniprot | |
K8 | Acetylation | Uniprot | |
K10 | Acetylation | Uniprot | |
K13 | Ubiquitination | Uniprot | |
S16 | Phosphorylation | Uniprot | |
C26 | S-Nitrosylation | Uniprot | |
K32 | Ubiquitination | Uniprot | |
Y41 | Phosphorylation | Uniprot | |
S42 | Phosphorylation | Uniprot | |
R44 | Methylation | Uniprot | |
Y48 | Phosphorylation | Uniprot | |
Y54 | Phosphorylation | Uniprot | |
Y58 | Phosphorylation | Uniprot | |
C62 | S-Nitrosylation | Uniprot | |
K68 | Acetylation | Uniprot | |
K68 | Ubiquitination | Uniprot | |
K73 | Acetylation | Uniprot | |
K73 | Sumoylation | Uniprot | |
K73 | Ubiquitination | Uniprot | |
K78 | Ubiquitination | Uniprot | |
R87 | Methylation | Uniprot | |
R93 | Methylation | Uniprot | |
Y95 | Phosphorylation | Uniprot | |
K100 | Acetylation | Uniprot | |
K100 | Ubiquitination | Uniprot | |
K109 | Ubiquitination | Uniprot | |
R118 | Methylation | Uniprot | |
K123 | Sumoylation | Uniprot | |
K123 | Ubiquitination | Uniprot | |
K136 | Ubiquitination | Uniprot | |
T145 | Phosphorylation | Uniprot | |
S148 | Phosphorylation | Uniprot | |
Y152 | Phosphorylation | Uniprot | |
K162 | Ubiquitination | Uniprot | |
K169 | Ubiquitination | Uniprot | |
T198 | Phosphorylation | P06493 (CDK1) | Uniprot |
K207 | Acetylation | Uniprot | |
K210 | Acetylation | Uniprot | |
K210 | Sumoylation | Uniprot | |
K210 | Ubiquitination | Uniprot | |
K229 | Acetylation | Uniprot | |
K237 | Acetylation | Uniprot | |
K246 | Acetylation | Uniprot | |
K246 | Ubiquitination | Uniprot | |
K252 | Ubiquitination | Uniprot | |
Y261 | Phosphorylation | Uniprot | |
Y269 | Phosphorylation | Uniprot | |
Y275 | Phosphorylation | Uniprot | |
K284 | Acetylation | Uniprot | |
K284 | Ubiquitination | Uniprot | |
R293 | Methylation | Uniprot | |
K301 | Acetylation | Uniprot | |
K301 | Ubiquitination | Uniprot | |
K312 | Acetylation | Uniprot | |
K312 | Methylation | Uniprot | |
K317 | Ubiquitination | Uniprot | |
K325 | Acetylation | Uniprot | |
K325 | Methylation | Uniprot | |
K325 | Ubiquitination | Uniprot | |
T332 | Phosphorylation | P06493 (CDK1) | Uniprot |
K337 | Acetylation | Uniprot | |
K337 | Ubiquitination | Uniprot | |
K344 | Acetylation | Uniprot | |
K344 | Ubiquitination | Uniprot | |
K347 | Ubiquitination | Uniprot | |
Y354 | Phosphorylation | Uniprot | |
K364 | Acetylation | Uniprot | |
K364 | Ubiquitination | Uniprot | |
K373 | Acetylation | Uniprot | |
K373 | Ubiquitination | Uniprot | |
K381 | Acetylation | Uniprot | |
Y383 | Phosphorylation | Uniprot | |
T384 | Phosphorylation | Uniprot | |
K388 | Acetylation | Uniprot | |
K388 | Ubiquitination | Uniprot | |
K395 | Acetylation | Uniprot | |
C417 | S-Nitrosylation | Uniprot | |
C420 | S-Nitrosylation | Uniprot | |
K429 | Acetylation | Uniprot | |
K429 | Ubiquitination | Uniprot | |
K434 | Ubiquitination | Uniprot | |
K442 | Ubiquitination | Uniprot | |
Y444 | Phosphorylation | Uniprot | |
K446 | Acetylation | Uniprot | |
K446 | Ubiquitination | Uniprot | |
K453 | Ubiquitination | Uniprot | |
C461 | S-Nitrosylation | Uniprot | |
K462 | Acetylation | Uniprot | |
K462 | Ubiquitination | Uniprot | |
Y476 | Phosphorylation | Uniprot | |
S481 | Phosphorylation | Uniprot | |
K486 | Ubiquitination | Uniprot | |
K513 | Acetylation | Uniprot | |
K513 | Ubiquitination | Uniprot | |
K523 | Ubiquitination | Uniprot | |
K530 | Acetylation | Uniprot | |
K530 | Ubiquitination | Uniprot | |
K533 | Ubiquitination | Uniprot | |
R543 | Methylation | Uniprot |
研究背景
Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
Cytoplasm. Nucleus.
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2. Forms a complex with HSPA8/HSC70, HSPCA/HSP-86 and HSPCB/HSP-84 (By similarity). Interacts with PACRG. Interacts with METTL21B. Interacts with HSP90/HSP90AA1; the interaction dissociates the PPP5C:HSP90AA1 interaction. Interacts with FLCN, FNIP1 and FNIP2. Interacts with HSPA8/HSC70 (By similarity). Interacts with HSP90AB1; upon SMYD2-dependent HSP90AB1 methylation.
The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.
研究領域
· Human Diseases > Neurodegenerative diseases > Prion diseases.
参考文献
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