ITPA Antibody - #DF6353
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6353, RRID:AB_2838317.
折りたたみ／展開
C20orf37; dJ794I6.3; HLC14-06-P; Inosine triphosphatase (nucleoside triphosphate pyrophosphatase); Inosine triphosphatase; inosine triphosphatase-A; Inosine triphosphate pyrophosphatase; Inosine triphosphate pyrophosphohydrolase; Itpa; ITPA_HUMAN; ITPase; My049; My049 protein; Non canonical purine NTP pyrophosphatase; Non standard purine NTP pyrophosphatase; NTPase; nucleoside triphosphate diphosphatase; Nucleoside triphosphate pyrophosphatase; OK/SW-cl.9; OTTHUMP00000030094; OTTHUMP00000160459; Putative oncogene protein hlc14-06-p;
免疫原
Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
- Q9BY32 ITPA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BY32 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| T14 | Phosphorylation | Uniprot | |
| K18 | Ubiquitination | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K56 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| C146 | S-Nitrosylation | Uniprot | |
| C154 | S-Nitrosylation | Uniprot | |
| K169 | Ubiquitination | Uniprot | |
| K172 | Ubiquitination | Uniprot |
研究背景
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Cytoplasm.
Ubiquitous. Highly expressed in heart, liver, sex glands, thyroid and adrenal gland.
Homodimer.
Belongs to the HAM1 NTPase family.
研究領域
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
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