MAOB Antibody - #DF6464
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6464, RRID:AB_2838426.
折りたたみ／展開
Adrenalin oxidase; Amine oxidase (flavin containing); Amine oxidase [flavin-containing] B; AOFB_HUMAN; MAO, brain; MAO, platelet; MAO-B; MAOB; MGC26382; Monoamine oxidase B; Monoamine oxidase type B; OTTHUMP00000023166; Tyramine oxidase;
免疫原
- P27338 AOFB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P27338 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| T43 | Phosphorylation | Uniprot | |
| Y44 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| Y60 | Phosphorylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| S131 | Phosphorylation | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| Y337 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| K456 | Ubiquitination | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot |
研究背景
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Mitochondrion outer membrane>Single-pass type IV membrane protein>Cytoplasmic side.
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
Belongs to the flavin monoamine oxidase family.
研究領域
· Human Diseases > Substance dependence > Cocaine addiction.
· Human Diseases > Substance dependence > Amphetamine addiction.
· Human Diseases > Substance dependence > Alcoholism.
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Amino acid metabolism > Arginine and proline metabolism.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Amino acid metabolism > Tryptophan metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Serotonergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
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For Research Use Only.
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